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| 牙髓创伤时牙髓PGE2、PGI2和TXA2浓度改变的研究 | |
| 引用本文： | 潘剑波,黄世光,王华东,胡巢凤,颜亮.牙髓创伤时牙髓PGE2、PGI2和TXA2浓度改变的研究[J].中国病理生理杂志,2002,18(11):1397-1399. |
| 作者姓名： | 潘剑波 黄世光 王华东 胡巢凤 颜亮 |
| 作者单位： | 1. 广州市第二人民医院口腔科, 广东广州510150; 2. 暨南大学医学院口腔系, 广东广州510632; 3. 暨南大学医学院病理生理学教研室, 广东广州510632 |
| 基金项目： | 国务院侨务办公室重点科研项目 (93 - 95 - 9) |
| 摘 要： | 目的:探讨前列腺素与牙髓炎的关系。方法:建立大鼠创伤性牙髓炎模型,动态观察创伤后大鼠牙髓的组织学改变和检测牙髓中PGE2,6-Keto-PGF1α和TXB2 浓度的变化。结果:创伤后大鼠牙髓呈明显炎症改变,PGE2,6-Keto-PGF1α和TXB2 浓度升高,在创伤 6h后达到高峰。结论:前列腺素参与急性牙髓炎的发病。 |
| 关 键 词： | 牙髓炎 血栓烷A2 前列腺素E类 前列腺素I类 |
| 文章编号： | 1000-4718(2002)11-1397-03 |
| 收稿时间： | 2002-04-27 |
Changes of PGE2, PGI2 and TXA2 concentration in rat traumatic pulpitis |
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| PAN Jian-bo ,HUANG Shi-guang ,WANG Hua-dong ,HU Chao-feng ,YAN Liang.Changes of PGE2, PGI2 and TXA2 concentration in rat traumatic pulpitis[J].Chinese Journal of Pathophysiology,2002,18(11):1397-1399. | |
| Authors: | PAN Jian-bo HUANG Shi-guang WANG Hua-dong HU Chao-feng YAN Liang |
| Affiliation: | 1. Department of Stomatology, Guangzhou Second Municipal Hospital, Guangzhou 510150, China; 2. Department of Stomatology, Medical College of Jinan University, Guangzhou 510632, China; 3. Department of Pathophysiology, Medical College of Jinan University, Guangzhou 510632, China |
| Abstract: | AIM: To study the relationship between prostaglandins and acute pulpitis. METHODS: Rat traumatic pulpitis model was established by pulp exposure. The kinetic pathological changes in dental pulpal tissues and changes of PGE2,6-Keto-PGF1α and TXB2 concentration in dental pulp were observed. RESULTS: After pulpal trauma, the dental pulp showed inflammatory changes and the concentrations of PGE2,6-Keto-PGF1α and TXB2 were increased, which peaked at 6 hour post-trauma. CONCLUSION: Prostaglandins play a significant role in the pathogenesis of pulpitis. |
| Keywords: | Pulpitis Thromboxane A 2 Prostaglandins E Prostaglandins I |
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