| 富锗大麦苗安全性评价 |
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| 引用本文： | 杜蓉,王晓洁,肖颜颜,王守海,闵凤霞.富锗大麦苗安全性评价[J].食品科学,2011,32(1):206-209. |
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| 作者姓名： | 杜蓉 王晓洁 肖颜颜 王守海 闵凤霞 |
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| 作者单位： | 鲁东大学生命科学学院 |
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| 基金项目： | 烟台市科学技术发展计划项目(2007152) |
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| 摘 要： | 目的：通过研究富锗大麦苗对小鼠的毒理作用，对其进行安全性评价。方法：用不同剂量富锗大麦苗汁连续灌胃小鼠20d，通过急性毒性实验、骨髓细胞微核实验和骨髓细胞染色体畸变实验，测定其对小鼠急性毒理和遗传毒理作用。结果：各实验组富锗大麦苗对小鼠经口半数致死量(LD50)大于1g/mL，动物体质量增长正常，未表现中毒现象；骨髓微核发生率和染色体畸变率均在正常范围内与生理盐水对照组比较无显著差异(P＞ 0.05)。结论：本实验中无受试小鼠中毒死亡现象，没有出现致畸突变现象，提示富锗大麦苗在本实验使用剂量范围内对小鼠不具有急性毒性和遗传毒性，是安全可靠的。
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| 关 键 词： | 富锗大麦苗 毒理作用 安全性评价 小鼠 |
| 收稿时间： | 2010-09-21 |
Evaluation of the Safety of Germanium-enriched Barley Seedlings |
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| DU Rong,WANG Xiao-jie,XIAO Yan-yan,WANG Shou-hai,MIN Feng-xia.Evaluation of the Safety of Germanium-enriched Barley Seedlings[J].Food Science,2011,32(1):206-209. |
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| Authors: | DU Rong WANG Xiao-jie XIAO Yan-yan WANG Shou-hai MIN Feng-xia |
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| Affiliation: | (College of Life Science, Ludong University, Yantai 264025, China) |
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| Abstract: | Objective:Safety evaluation of germanium-enriched barley seedlings(EGBS) was conducted by investigating the toxicological effect of EGBS in mice.Methods:The acute toxic effect of EGBS in healthy mice orally administered different doses of EGBS for 20 successive days was evaluated,and for the evaluation of genetic toxic effect,mouse bone marrow micronucleus and chromosomal aberration tests were used.Results:All EGBS dose groups presented a median lethal dose(LD50)>1 g/mL and normal animal body weight gain,wi... |
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| Keywords: | germanium-enriched barley seedling toxicity effect safety evaluation mice |
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