| 肝动脉栓塞微球的动物体内行为和药效学研究 |
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| 引用本文： | 陈庆华.肝动脉栓塞微球的动物体内行为和药效学研究[J].中国医药工业杂志,1990,21(10):472-477. |
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| 作者姓名： | 陈庆华 |
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| 作者单位： | 上海医药工业研究院 上海 |
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| 摘 要： | 肝动脉栓塞微球是用于治疗中晚期肝癌的新剂型。通过动脉插管即可将微球栓塞至肝癌邻近的末梢动脉血管,起阻断血流和在局部缓释药物的双重作用。本文结合几年来对MTX明胶微球和顺铂-乙基纤维素微球的基础研究工作,综述微球栓塞后在动物体内的行为和药效学,并介绍了初期临床结果。
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| 关 键 词： | 微球 肝动脉栓塞 体内过程 药效学 |
STUDY ON IN VIVO BEHAVIOR OF MICROSPHERES IN ANIMALS AND EFFECT OF HEPATIC ARTERIAL EMBOLIZATION ON HUMAN LIVER CANCER |
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| Authors: | CHEN Qing-Hua |
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| Affiliation: | CHEN Qing-Hua Shanghai Institute of Pharmaceutical Industry. Shanghai 200433 |
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| Abstract: | The microsphere for hepatic arterial embolization is a newdosage form for treatment of non-resectable liver cancer. Using ultra-selectivecatheter, the microspheres could be sent to the end vessels of hepatic artery nearthe cancer and block the blood stream as well as release slowly the drug entrap-ped locally. Combining the basic research of MTX-gelatin microspheres andcis-platin-ethyl cellulose microspheres, their in vivo behavior in animals, the effectin treatment of liver cancer after arterial embolization, and the preliminaryclinical results were reviewed briefly. |
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| Keywords: | microspheres for hepatic arterial embolization the vivo behavior therapeutic effectiveness |
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