猪繁殖与呼吸综合征病毒E蛋白研究进展

猪繁殖与呼吸综合征(PRRS)是由猪繁殖与呼吸综合征病毒(PRRSV)引起的高度接触性传染病,主要引起母猪繁殖障碍,表现为妊娠后期流产、死胎、木乃伊胎及弱仔。E蛋白是由ORF2b编码的一个非糖基化结构蛋白,分子质量约10 ku,具有影响病毒复制的作用,促使病毒粒子脱壳,但对病毒的装配不起作用,认为具有离子通道蛋白活性。作者就E蛋白的特性、亚细胞定位和拓扑结构、离子通道活性作一综述。

Research Progress on Protein E of Porcine Reproductive and Respiratory Syndrome Virus

Porcine reproductive and respiratory syndrome(PRRS)is a highly infectious disease of swine caused by porcine reproductive and respiratory syndrome virus(PRRSV). PRRS caused reproductive failure in sows,such as abortion,fetal losses, premature,parturition, mummies,stillbirths and neonatal death. E protein was encoded by ORF2b, a non-glycosylated structural protein, which size was 10 ku.It can affect viral replication, prompt the shelling of the virus particles, but do not work on the assembly of the virus, and have the ion channel protein activity. The characteristics, subcellular localization and topology,ion channel protein activity of E protein were summarized in this paper.