| 鼻息肉患者外周血Th17/Treg细胞比率的失衡及其临床意义 |
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| 引用本文： | 沈唠,洪苏玲,胡国华,唐新业,寇巍,潘常凯.鼻息肉患者外周血Th17/Treg细胞比率的失衡及其临床意义[J].细胞与分子免疫学杂志,2011,27(12):1339-1342. |
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| 作者姓名： | 沈唠 洪苏玲 胡国华 唐新业 寇巍 潘常凯 |
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| 作者单位： | 1. 重庆医科大学附属第一医院耳鼻咽喉科,重庆400016;眼科学重庆市市级重点实验室,重庆400016
2. 重庆医科大学附属第一医院耳鼻咽喉科,重庆,400016 |
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| 摘 要： | 目的:观察鼻息肉(NP)患者外周血Th17和Foxp3+ CD4+ CD25+调节性T细胞(Treg)的水平及其与临床病情的关系,初步探讨Th17/Treg细胞的比率失衡在NP发病机制中的作用和意义.方法:NP患者根据鼻内镜和鼻窦CT评分的结果分为1组(鼻内镜检查评分:2～8分;CT检查评分:3～10分,n=23)和2组(鼻内镜检查评分:8～12分;CT检查评分:10～19分,n=23),选取10例单纯鼻中隔偏曲患者作为对照组.采用流式细胞术检测外周血中Th17和Treg的比例,并对Th17/Treg的比率及鼻内镜、鼻窦CT评分进行相关性分析.结果:两组NP患者外周血中Th17细胞比率明显高于对照组(P＜0.01),且2组高于1组(P＜0.05).两组NP患者外周血中Treg细胞的比率明显低于对照组(P＜0.01),但两组间差异无统计学意义.两组NP患者Th17/Treg细胞的比率明显高于对照组(P＜0.01),且两组间差异显著(P＜0.05).同时,相关性分析结果显示,Th17/Treg细胞的比率与鼻内镜、鼻窦CT评分呈正相关(r=0.562,r=0.667,P＜0.01).结论:NP患者外周血中Th17细胞比率增加和Treg细胞比率降低所致的Th17/Treg细胞比率失衡,可能在NP的发生发展中起着重要作用.Th17/Treg比率失衡的程度可能与临床病情严重程度密切相关.
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| 关 键 词： | 鼻息肉 Th17细胞 调节性T细胞 炎症 |
Imbalance of Thl7/Treg cell ratio in peripheral blood of patients with nasal polyposis and its clinical significance |
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| SHEN Yarng
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HONG Su-ling
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HU Guo-hua
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TANG Xin-ye
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KOU Wei
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PAN Chang-kai.Imbalance of Thl7/Treg cell ratio in peripheral blood of patients with nasal polyposis and its clinical significance[J].Journal of Cellular and Molecular Immunology,2011,27(12):1339-1342. |
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| Authors: | SHEN Yarng HONG Su-ling HU Guo-hua TANG Xin-ye KOU Wei PAN Chang-kai |
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| Affiliation: | SHEN Yang1,2,HONG Su-ling1,HU Guo-hua1,TANG Xin-ye1,KOU Wei1,PAN Chang-kai1,2 1Department of Otorhinolaryngology,the First Affiliated Hospital of Chongqing Medical University,2Chongqing Key Laboratory of Ophthalmology,Chongqing 400016,China |
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| Abstract: | AIM: To observe the distribution of Th17 cells and Foxp3+CD4+CD25+ regulatory T cells in peripheral blood of patients with nasal polyposis(NP) and their correlation with clinical patients' condition,and to explore the role of Th17/Treg cell ratio imbalance in pathogenesis of nasal polyposis and significance.METHODS: The frequencies of Th17 cells and Treg cells were determined in 46 patients with NP and 10 controls by flow cytometry.The 46 patients were divided into two groups according to endoscopy score an... |
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| Keywords: | nasal polyposis Th17 cell regulatory T cell inflammation |
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