TDI评价亚临床型甲状腺功能减退患者左室功能

摘要：目的应用组织多普勒超声心动图评价亚临床型甲状腺功能减退（SH）患者左室功能。方法采集29例SH及25例正常对照组每个人的常规超声心动图图像及二尖瓣环的组织多普勒图像，记录下参数包括：二尖瓣血流频谱E峰及A峰，E／A、TDI收缩期峰值速度（S），射血时间（ET）、等容收缩期峰值速度（IVV）、等容收缩期加速度（IVA）、等容加速时间（AT）、舒张早期峰值（E’）与舒张晚期峰值（A’）及E’／A’、E／E’比值、等容舒张时间（IVRT），计算出心肌做功指数MPIMPI=（IVCT＋IVRT）／ET]。结果SI-I组A值较正常组高，E／A较正常组低，E’值较正常组低，E／E’值较正常组高，且均具有显著的统计学意义（P〈0．05）。IVV及IVA值较对照组减低，等容收缩期时间（IVCT）较对照组高，MPI较对照组低，且两组数值均具有明显差别（P〈0．05）。结论亚临床型甲状腺功能减退患者左室收缩及舒张功能减退。

Evaluation of left ventricular functions using TDI in patients with subclinical hypothyroidism

Objective To evaluated left ventricle(LV) functions by tissue Doppler imaging(TDI) in patients with subclinical hypothyroidism(SH).Methods Twenty-nine patients with newly diagnosed SH and 25 healthy subjects were evaluated by standard echocardiography and TDI.The following parameters were measured: E,A,E/A,S,peak myocardial velocity during isovolumic contraction(IVV),isovolumic myocardial acceleration(IVA),E’and A’,E’/A’and E/E’,and isovolumic relaxation time(IVRT).Results Compared to healthy controls,patients with SH had higher LV mitral A velocity,lower E/A ratio,lower E’velocity,and higher E/E’ratio,suggesting significant LV diastolic dysfunction(P<0.05).SH group also had lower IVV and IVA,and higher isovolumic contraction time,and had lower myocardial performance index(MPI),suggesting LV subclinical systolic dysfunction.Conclusion Our data suggest that SH is associated with LV systolic and diastolic dysfunction.