| 棉酚单侧衍生物的合成及其口服抗生育活性研究 |
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| 引用本文： | 孔爱华,薛慧中,郭争鸣,吴国沛,赵世兴,游根娣,顾芝萍.棉酚单侧衍生物的合成及其口服抗生育活性研究[J].中国药物化学杂志,1993(2). |
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| 作者姓名： | 孔爱华 薛慧中 郭争鸣 吴国沛 赵世兴 游根娣 顾芝萍 |
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| 作者单位： | 南京药物研究所，南京药物研究所，南京药物研究所，南京药物研究所，上海药物研究所，上海药物研究所，上海药物研究所 南京 210009，南京 210009，南京 210009，南京 210009，上海 200031，上海 200031，上海 200031 |
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| 摘 要： | 本文报道单醛棉酚和单苯胺棉酚合成工艺的改进,即采用新的有效的分离方法,提高收率,从而首次完成了这两个化合物的雄性大鼠口服抗生育实验。文中还首次报道了单醛棉酚的mp,UV,IR,MS及完整的~1H-NMR数据并阐明了单醛棉酚在DMSO-d_6溶剂中同时共存着醛式与内醚式两种互变异构体。
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| 关 键 词： | 棉酚 棉酚单侧衍生物 单醛棉酚 单苯胺棉酚 口服抗生育活性 |
STUDIES ON THE SYNTHESIS OF GOSSYPOL UNSYMMETRIC DERIVATIVES AND THEIR ANTIFERTILITY ACTIVITY BY ORAL ADMINISTRATION |
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| Kong Aihua Xue Huizhong Guo Zhengming Wu Guopei.STUDIES ON THE SYNTHESIS OF GOSSYPOL UNSYMMETRIC DERIVATIVES AND THEIR ANTIFERTILITY ACTIVITY BY ORAL ADMINISTRATION[J].Chinese Journal of Medicinal Chemistry,1993(2). |
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| Authors: | Kong Aihua Xue Huizhong Guo Zhengming Wu Guopei |
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| Abstract: | The preparations of 8-dealdehydogossypol and monoanilinogossypol were improved to meet the needs of oral antifertility tests. For the first time,the mp, UV,IR,MS,~1H-NMR data of 8-dealdehydogossypol were given and its two isomers in DMSO-d_6 were discussed. |
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| Keywords: | Gossypol Gossypol unsymmetric derivative 8-Dealdehydogossypol Monoanilinogossypol Antifertility activity |
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