胺碘酮和普罗帕酮治疗阵发性室上性心动过速的效果比较

目的比较胺碘酮和普罗帕酮治疗阵发性室上性心动过速的疗效。方法将88例阵发性室上性心动过速患者随机分为两组,A组44例患者给予胺碘酮治疗,B组44例患者给予普罗帕酮治疗。结果两组复律成功率比较,差异无统计学意义(P>0.05);A组复律时间长于B组,复律时间分布较B组差,不良反应发生率低于B组,差异均有统计学意义(P<0.05)。结论胺碘酮和普罗帕酮对阵发性室上性心动过速的治疗各有利弊,普罗帕酮见效快、患者耐受差,适用于无严重器质性心脏病及心功能正常者;而胺碘酮见效较慢、不良反应少、适应证广,适用于器质性心脏病及心功能不全患者。

Comparison on Effect of Amiodarone and Propafenone Treating Paroxysmal Supraventricular Tachycardia

Objective To compare the efficacy of amiodarone and propafenone treating paroxysmal supraventricular tachycardia. Methods 88 cases with paroxysmal supraventricular tachycardia were selected and divided into two groups randomly. The A group for 44 cases were treated with amiodarone, and the B group for 44 cases were treated with propafenone. Results The difference for the successful rate of cardioversion between two groups had no statistical significance（P〈0.05）. The cardioversion time of A group was longer than that of B group, and the cardioversion time distribution of A group was worse than that of B group, the incidence rate of adverse reactions in A group was lower than that of B group ,which had statistical significance （P〈0.05）. Conclusion Propafenone and propafenone treating paroxysmal supraventricular tachycardia has advantages and disadvantages. Amiodarone has the advantages that the effect is fast, the patients have poor tolerance and it is applied to the patients with normal cardiac function and without organic heart disease, and amiodarone has the advantages that the effect is slow, there are few adverse reactions, there are wide range of indications, and it is applied to patients with organic heart disease and cardiac insufficiency.