健脾消糖颗粒对糖尿病前期胰岛功能的影响

目的： 观察中药制剂健脾消糖颗粒治疗糖尿病前期的疗效及对患者胰岛功能的影响。方法： 将117例糖尿病前期患者随机分为治疗组与对照组，治疗组59人，对照组58人，两组均进行健康教育与生活干预治疗。治疗组服用健脾消糖颗粒与阿卡波糖片治疗，对照组单纯服用阿卡波糖片。疗程为6个月，比较两组治疗前后空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白（HbA1c），空腹胰岛素（INS），胰岛素抵抗指数（IR），胰岛素敏感指数（ISI），Homaβ细胞功能指数的前后变化。结果： 两组治疗后FPG，2 hPG，HbA1c下降（P<0.05），与对照组比较，治疗组下降更明显（P<0.01），治疗组与对照组FINS，HOMA-IR下降（P<0.05）与对照组比较，治疗组下降更明显（P<0.01），ISI，胰岛素分泌指数（HOMA-B）上升（P<0.05），与对照组比较，治疗组上升更明显（P<0.01）。结论： 阿卡波糖片和健脾消糖颗粒均能改善糖尿病前期患者的FPG，2 hPG，HbA1c的水平和胰岛功能，加用健脾消糖颗粒的效果更加显著。

Effect of Jianpi Xiaotang Granule on Prediabetic State

Objective: To observe clinical effect of Jianpi Xiaotang granule on prediabetic state. Method: One hundred and seventeen cases with diabetes mellitus(DM)were divided into treatment group of 59 cases and control group of 58 cases both groups received health education and life intervention treatment.The treatment group received Jianpi Xiaotang cranule and acarbose tablets and the control group was given the acarbose tablets.The treatment course lasted six months and the changes of fasting plasma glucose(FPG),2 h plasma glucose(2 hPG),hermoglobins Alc(HbA1c), fasting inslulin(FINS),insulin resistance(IR),insulin sensitivity index(ISI), homeostasis model assessment-B(HOMA-B) was observed. Result: The levels of FPG,2 hPG,HbA1c were reduced significantly(P<0.05),FPG, HbA1c was reduced more significantly(P<0.01).The levels of FINS and IR was reduced (P<0.05) compared with control group, was reduced significan tly(P<0.01).The levels of ISI and HOMA-B was improved(P<0.05,P<0.01). Conclusion: Both Jianpi Xiaotang granule and acarbose can reduce the levels of the FINS,IRFPG,2 hPG,HbA1c and improve the levels of the ISI,HOMA-B.The reinforcing spleen and hypoglycemic granule significantly improve the pancreas islet functions.