Prins反应的研究和应用现状

结合Prins反应的发展历史，概述了近年来Prins反应的最新研究及应用现状。目前Prins反应有直接热缩合反应和催化合成反应两大类，本文分析了这两大类反应的优势和不足，指出了未来催化合成反应是Prins反应研究的重点。Prins反应的催化剂包括液体酸催化剂、固体酸催化剂和固体碱催化剂等，而离子液体催化剂、杂多酸催化剂、竹炭磺酸催化剂等高效且环境友好型催化剂是今后研究发展的重点。同时概述了Prins反应在化工、农药、香料、医药、天然大分子合成等方面的应用，最后提出了Prins反应未来在新型催化剂、相关合成方法学、石油化工和天然产物全合成等相关领域发展方向的展望。

Current research and application situation in Prins reaction

According to the development history of Prins reaction,the present research and application situation of Prins reaction were summarized in this paper.At present,the Prins reaction takes place through direct thermal condensation way without catalysts or catalytic synthesis reaction.The advantage and disadvantage of these two kinds of reaction were analyzed.We find the catalytic synthesis reaction was the topic of the research in the future.The catalysts of Prins reaction include liquid acid catalysts,solid acid catalysts,solid base catalysts.The development of high efficient and environment friendly catalysts,such as ionic liquid catalysts,heteropoly acid catalysts and the bamboo charcoal catalysts,were the topic of the research in the future.The applications of the Prins reaction in the field of chemical industry,pesticides,spice and natural polymer synthesis were reported in this paper.Finally,the development of Prins reaction in novel catalysts,relevant synthetic methodologies,petrochemical industry and synthesis of natural products were briefly reviewed in this paper.