E-cadherin在胃腺癌组织中的表达及其临床意义

目的:探讨上皮钙黏蛋白E（E-cadherin）在胃腺癌组织中的表达及其临床意义。方法:收集61例我院胃腺癌组织和其癌旁正常组织的石蜡包块以及患者的临床病理资料。免疫组化法检测E-cadherin在胃腺癌组织及癌旁正常组织中的表达，通过自动化图像分析系统对结果进行定量分析，统计学分析E-cadherin的表达及其与胃癌临床病理特征的关系。结果:E-cadherin在胃癌组织表达明显低于相应的癌旁组织（P＜0.05）；E-cadherin的表达下调与胃腺癌TNM分期、分化程度和浸润深度相关（P＜0.05），与性别、年龄、淋巴结转移无明显相关（P＞0.05）。结论:E-cadherin在胃腺癌组织中表达下调，提示E-cadherin可能在胃癌的侵袭过程中起重要作用。

The expressions and clinical significance of E-cadherin in gastric adenocarcinoma

Objective:To elucidate the expression of E-cadherin and its clinical significance in the gastric adenocarcinoma.Methods:A total of 61 gastric adenocarcinoma and adjacent normal tissues paraffin embedded tissues specimens and clinical factors were collected in our hospital.The expression of E-cadherin in gastric adenocarcinoma and adjacent normal tissues was determined by Immunohistochemically (IHC).IHC result was performed using automated digital image analysis by Image-Pro Plus 6.0 image analysis software.The association of E-cadherin expressions with the patients' clinicopathological features was investigated.Results:The expression of E-cadherin was significantly downregulation in gastric adenocarcinoma (P＜0.01).The value of E-cadherin downregulated was significantly correlated with TNM stages (P＜0.05),differentiation (P＜0.05) and tumor invasion depth (P＜0.05),and not related with gender,age,tumor size and lymphatic metastasis (P＞0.05).Conclusion:In gastric adenocarcinoma,E-cadherin was downregulated,which indicated that E-cadherin may play a role in the carcinogenesis,invasion of the gastric adenocarcinoma.