| 两个Galaxamide环五肽类似物的合成 |
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| 引用本文： | 徐显杰,邱少玲,徐石海.两个Galaxamide环五肽类似物的合成[J].精细化工,2013,30(3):313-319. |
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| 作者姓名： | 徐显杰 邱少玲 徐石海 |
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| 作者单位： | 暨南大学生命科学技术学院化学系,广东广州,510632 |
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| 基金项目： | 国家自然科学基金，广东省计划项目，天河区项目 |
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| 摘 要： | 以亮氨酸和苯丙氨酸为起始原料,改变其环合位点,优化其合成路线,合成了两个Galaxamide环五肽类似物,其环合收率近50%。使用反相HPLC进行分离纯化,通过1HNMR、13CNMR和MS对其结构进行表征。
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| 关 键 词： | 环五肽 环合 海洋生物环肽 医药与日化原料 |
Synthesis of Two Novel Pentapeptides Galaxamide Analogues |
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| XU Xian-jie,QIU Shao-ling,XU Shi-hai.Synthesis of Two Novel Pentapeptides Galaxamide Analogues[J].Fine Chemicals,2013,30(3):313-319. |
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| Authors: | XU Xian-jie QIU Shao-ling XU Shi-hai |
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| Affiliation: | *(Department of Chemistry,College of Life Science and Technology,Jinan University,Guangzhou 510632,Guangdong,China) |
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| Abstract: | With leucine and phenylalanine as starting materials,two new pentapeptides were totally synthesized through changing the cyclic sites and optimizing the route of synthesis.The yield of cyclization reaction was up to 50%.The products were isolated and purified by RP-HPLC,and the compound structures were characterized by means of 1HNMR,13CNMR and MS. |
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| Keywords: | cyclic pentapeptide cyclization marine Galaxamide analogues drug and cosmetic materials |
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