| 乳腺癌放疗联合PD-1/PD-L1抑制剂研究进展 |
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| 引用本文： | 姜杰,黄伟.乳腺癌放疗联合PD-1/PD-L1抑制剂研究进展[J].中华放射肿瘤学杂志,2021,30(4):424-428. |
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| 作者姓名： | 姜杰 黄伟 |
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| 作者单位： | 潍坊医学院 261053;山东省肿瘤防治研究院(山东省肿瘤医院)放疗科 山东第一医科大学(山东省医学科学院),济南 250117 |
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| 基金项目： | 国家自然科学基金面上项目(81773232);山东省政府泰山学者青年专家项目(tsqn201909187) |
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| 摘 要： | 放疗可以增强肿瘤特异性免疫反应,同时为免疫药物提供作用靶点,以PD-1/PD-L1为代表的免疫检查点阻断剂联合放疗增强抗肿瘤活性,并且具有远隔效应。本文就放疗联合PD-1/PD-L1抑制剂治疗乳腺癌的基础研究、临床研究进展及面临的挑战做一综述。
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| 关 键 词： | 乳腺肿瘤/放射疗法 乳腺肿瘤/免疫疗法 程序性死亡-1/程序性死亡配体-1 进展 |
| 收稿时间： | 2020-03-29 |
Research progress on radiotherapy combined with PD-1/PD-L1 inhibitors in the treatment of breast cancer |
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| Jiang Jie,Huang Wei.Research progress on radiotherapy combined with PD-1/PD-L1 inhibitors in the treatment of breast cancer[J].Chinese Journal of Radiation Oncology,2021,30(4):424-428. |
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| Authors: | Jiang Jie Huang Wei |
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| Affiliation: | Weifang Medical University, Weifang 261053, China;Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Ji'nan 250117, China |
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| Abstract: | Radiotherapy has been proven to enhance tumor-specific immune response and provide targets for immune drugs. Immune checkpoint inhibitors represented by PD-1/PD-L1 combined with radiotherapy can enhance anti-tumor activity and exert abscopal effect. In this article, research progress on the basic study and clinical trials and challenges of radiotherapy combined with PD-1/PD-L1 inhibitors in the treatment of breast cancer were reviewed. |
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| Keywords: | Breast neoplasm/radiotherapy Breast neoplasm/immunotherapy PD-1/PD-L1 Progress |
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