| HPLC法测定肠舒灵胶囊中盐酸小檗碱含量 |
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| 引用本文： | 刘龙忠.HPLC法测定肠舒灵胶囊中盐酸小檗碱含量[J].中国医药导报,2008,5(36):31-32. |
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| 作者姓名： | 刘龙忠 |
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| 作者单位： | 贵州省遵义医学院附属医院药剂科,贵州遵义,563003 |
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| 摘 要： | 目的：建立肠舒灵胶囊中盐酸小檗碱含量测定方法。方法：色谱柱为Phenomenex C18（150mm×4.6mm,5μm）;乙腈-水（每100ml加磷酸二氢钾0.34g与十二烷基磺酸钠0.17g）（47.5∶52.5）为流动相;检测波长346nm;流速1.0ml/min。结果：盐酸小檗碱线性范围为0.0605～0.5445μg,r=0.9999,平均回收率为99.88%,RSD=1.50%。结论：该法可用于肠舒灵胶囊的质量控制。
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| 关 键 词： | 盐酸小檗碱 肠舒灵胶囊 HPLC |
Determination of berberine hydrochloride in Changshuling Capsules by HPLC |
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| LIU Long-zhong.Determination of berberine hydrochloride in Changshuling Capsules by HPLC[J].China Medical Herald,2008,5(36):31-32. |
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| Authors: | LIU Long-zhong |
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| Affiliation: | LIU Long-zhong (Department of Pharmacy, the Affiliated Hospital of Zunyi Medical College, Guizhou Province, Zunyi 563003, China) |
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| Abstract: | Objective：To establish a HPLC method for determination of berberine hydroehloride in Changshuling Capsules. Methods ：The chromatographic column of Phenomenex C18 （150 mm×4.6 mm,5 μm）was selected, the mobile phase was aeetonitrile-water（KH2PO4 0.34 g and CH3（CH2）CHOSO3Na 0.17 g/100 m1）（47.5：52.5） with the flow rate of 1.0 ml/min, the detection wavelength was 346 nm. Results ：The linear range of berberine hydrochloride was 0.060 5-0.544 5 μg,r=-0.999 9, the average recovery was 99.88% ,RSD=1.50%. Conclusion：This HPLC method could be used for the quality control of Changshuling Capsules. |
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| Keywords: | HPLC |
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