| 喉癌组织Bc1-2和Bax基因蛋白表达及其临床相关性研究 |
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| 引用本文： | 张超,王明方,王建军,张洛灵.喉癌组织Bc1-2和Bax基因蛋白表达及其临床相关性研究[J].河南科技大学学报(医学版),2001,19(1):1-2. |
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| 作者姓名： | 张超 王明方 王建军 张洛灵 |
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| 作者单位： | 1. 洛阳医专附属医院耳鼻喉科,
2. 洛阳医专微生物教研室, |
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| 摘 要： | 目的 探讨喉癌组织Bc1 2和Bax基因蛋白表达与喉癌发生、发展的关系。方法 采用免疫组化SP法测定 5例正常人声带组织和 73例喉癌组织标本中Bc1 2和Bax基因蛋白表达。结果 喉癌组织中Bc1 2基因蛋白表达阳性检出率 45 .2 % ,喉癌组织中Bax基因蛋白达阳性检出率 6 0 .3% ,与正常人相比 ,均无显著性差异 (P >0 .0 5 )。喉癌组织中Bc1 2及Bax基因蛋白的表达呈明显的负相关关系 ,r值 - 0 .71,P <0 .0 5。结论 喉癌组织中Bc1 2和Bax基因蛋白表达的失调可能与喉癌的发生、发展有关。
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| 关 键 词： | 喉癌 Bc12基因 Bax基因 细胞凋亡 |
| 文章编号： | 1008-7702(2001)01-0001-02 |
| 修稿时间： | 2000年12月7日 |
Study of Bc1-2 and Bax Expression in Laryngeal Carcinoma and its Clinical Relationship |
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| Zhang Chao,Wang Mingfang,Wang Jianjun,et al.Study of Bc1-2 and Bax Expression in Laryngeal Carcinoma and its Clinical Relationship[J].Journal of Henan University of Science & Technology:Medical Science,2001,19(1):1-2. |
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| Authors: | Zhang Chao Wang Mingfang Wang Jianjun |
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| Affiliation: | The Affilliated Hospital of Luoyang Medical College |
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| Abstract: | Objective To study the relationship between expression of Bc1 2 and Bax in laryngeal carcinoma. Methods Using monoclonal antibody for Bc1 2 and Bax gene protetin, 33 cases of laryngeal carcinoma were stained by SP immunohistochemistry. Results The Bc1 2 and Bax positive rates of laryngeal carcinoma were 45.2%and 60.3% respectively. There was significant relationship between expression of Bc1 2 and that of Bax in laryngeal carcinoma. Conclusion There is intimate relationship between abnormal expression of Bc1 2 and Bax and laryngeal carcinoma. |
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| Keywords: | laryngeal carcinoma Bc1 2 gene Bax gene apoptosis |
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