骨囊肿、骨巨细胞瘤和骨肉瘤的计算机图象定量研究

目的:研究和解决骨巨细胞瘤的传统组织学分级与生物学行为不甚相符的问题.方法:利用自动图象分析仪对13例骨囊肿,51例骨巨细胞瘤(GCT)和15例骨肉瘤,共计79例标本进行了8项参数的形态定量研究.结果:在8项参数中,核X_6(核圆度)、X_7(核椭率)在不同肿瘤或分级的两两比较中全部无显著性差异;其余6项参数GCTⅠ、Ⅱ级均无显著性差异,而 GCTⅠ级与骨囊肿、Ⅲ级骨肉瘤各组间均有显著性差异,GCTⅡ级与骨囊肿、Ⅲ级骨肉瘤各组织间也有显著性差异.结论:经计算机图象定量研究,将8项参数经多元逐步判别分析,结果优选出有较多诊断价值的3项参数见、X_1、X_5、X_8,并依次建立判别函数方程(回归方程).

Cytomorphometric analysis of human bone cyst, giant cell tumor of bone and osteosarcoma

Objective: :This study was designed to solve the problem that the tradititional tissure classification on giant cell tumor of bone(GCT) did not accord with its biological behavior. Method: The automatic image analyser was Applied morphometric study in 79 sepeciment. There were 13 cases of bone cyst, 51 cases of giant cell of bone, 15 cases of osteosarcoma. . Eight parmeters were morphomtrically mesured and calculated. Results:It was showed that X_(6)(nuclear circular degree), X7(nuclear elipicity) of 8 pa-rameters were no significant each and all tumor or system of grade. The author thought other 6 patameters were useful, there was no signifficant difference bettween gread I and II of GCT. There was significant difference among grade between I ? II of GCT and bone cyst, grade III GCT and osteosarcome. Conclusion: The author also established an regression equation on quantitative morpho-metric analysis, which was reference value for pathology clinical diagnesis.