儿童腹股沟疝先天性危险因素的病例对照研究

摘要] 目的 探讨儿童腹股沟疝发生的先天性危险因素。方法 采用以医院为基础的1:1配对病例对照研究方法，对201例0～6岁腹股沟疝患儿和201例0～6岁对照儿童的情况进行问卷调查，用χ2检验和条件Logistic回归对所收集资料进行单因素及多因素分析，计算OR值（比值比）及OR值的95%CI（可信区间）。结果 儿童腹股沟疝家族史（OR=12.178，95%CI：5.495~26.990）、母亲孕前1月和孕期头3个月贫血史（OR=5.143，95%CI：2.021~13.088）、母亲孕前1月和孕期头3个月饮茶习惯（OR=1.800，95%CI：1.039~3.119）、母亲孕前1月和孕期头3个月腌制品摄入（OR=2.339，95%CI：1.298~4.217）、母亲孕前1月和孕期头3个月被动吸烟史（OR=1.851，95%CI：1.064~3.222）与儿童腹股沟疝的发病有关。结论 儿童腹股沟疝家族史、母亲孕前1月和孕期头3个月贫血、被动吸烟、饮茶习惯和腌制品摄入是儿童腹股沟疝发生的先天性危险因素。 关键词]腹股沟疝 儿童 先天性，危险因素 配对病例对照研究

A case-control study on the congenital risk factors of inguinal hernia in children

Objective To explore the congenital risk factors of inguinal hernia in children. Methods A 1:1 pair matched case-control study which based on hospital group data was performed. 201 0~6 years old inguinal hernia cases and 201 0~6 years old controls were enrolled. Parents were interviewed for the characteristics before and during gestation. Chi-square test, conditional Logistic regression model was used for single factor and multivariate factor analysis to estimate odds ratios(OR) and the 95% confidence interval(CI). Results Children's positive family history of inguinal hernia (OR=12.178, 95%CI: 5.495~26.990), maternal anemia during the period of one month before or three months after pregnancy (OR=5.143, 95%CI: 2.021~13.088), maternal custom of tea during the period of one month before or three months after pregnancy during the first trimester of pregnancy (OR=2.339, 95%CI: 1.298~4.217), maternal passive smoking during the period of one month before or three months after pregnancy (OR=1.851, 95%CI: 1.064~3.222) were associated with children's inguinal hernia. Conclusion: children's positive family history of inguinal hernia, maternal anemia, passive smoking, custom of tea and eating pickle during the period of one month before or three months after pregnancy are the congenital factors of children's inguinal hernia.