PGC-1α与线粒体O生成调控在心血管疾病中的作用

线粒体是一类高度活跃的细胞器,在细胞能量代谢等生命活动中具有重要的作用。线粒体生成,即线粒体的增殖以及线粒体系统合成和个体合成的过程。近年来研究提示,线粒体生成与线粒体的功能调节密切相关,而过氧化物酶体增殖物激活受体γ辅激活因子-1α(peroxisome proliferator-ac-tivated receptor gamma co-activator,PGC-1α)可能是线粒体生成的关键调控因子。特别是在心血管系统中,PGC-1α信号途径调控的线粒体生成可能是维持和修复心肌细胞和血管内皮细胞等心血管系统细胞线粒体功能的主要机制之一,在心力衰竭、心肌肥大、糖尿病心血管并发症等心血管疾病的发生与发展过程中具有重要作用。PGC-1α作为心血管疾病疾病预防和治疗的潜在靶标,将有可能为心血管疾病的防治提供新的策略。

Role of PGC-1α and mitochondrial biogenesis in cardiovascular diseases

Mitochondrion,a class of highly active organelles,plays an important role in energy metabolism of cellular and other vital activities.Mitochondrial biogenesis is the process of mitochondrial multiplication,system synthesis and individual synthesis.Recent studies have shown that mitochondrial biogenesis is closely related to mitochondrial function.Peroxisome proliferator-activated receptor gamma co-activator(PGC-1α) may be a key regulatory factor of mitochondrial biogenesis.Especially in cardiovascular system,mitochondrial biogenesis regulated by PGC-1α signaling pathway,could be one of the major mecha-nisms for maintaining and repairing mitochondrion function in cardiovascular system such as myocardial cells and vascular endothelial cells.PGC-1α plays an important role in the occurrence and development of cardiovascular diseases such as heart failure,cardiac hypertrophy and diabetic cardiomyopathy.As a potential target,PGC-1α could provide a new therapeutic strategy for the prevention and treatment of cardiovascular diseases.