天冬氨酸对脂多糖刺激断奶仔猪生长性能、血细胞分类计数和血液生化指标的影响

本试验旨在研究天冬氨酸(ASP)对脂多糖(LPS)刺激断奶仔猪生长性能、血细胞分类计数和血液生化指标的影响。试验选用24头断奶仔猪,分为对照组、LPS组、LPS+0.5%ASP组(0.5%ASP)、LPS+1.0%ASP组(1.0%ASP)。结果表明:0.5%和1.0%ASP可缓解LPS刺激导致的日增重的降低(P<0.05);注射LPS 4 h后,0.5%或1.0%ASP可显著缓解LPS刺激导致的淋巴细胞比例、血小板数量的降低和嗜酸性粒细胞比例的升高,增加红细胞平均血红蛋白(HGB)浓度(P<0.05);注射LPS 24 h后,0.5%和1.0%ASP可显著缓解嗜中性粒细胞数量、嗜中性粒细胞比例的升高和淋巴细胞比例的降低(P<0.05);0.5%或1.0%ASP可显著缓解LPS刺激引起的谷丙转氨酶、谷草转氨酶、碱性磷酸酶、尿素氮、血糖的升高和谷丙转氨酶/谷草转氨酶的降低(P<0.05)。结果显示,ASP缓解了LPS刺激所导致的生长抑制和应激反应。

Effect of Aspartic Acid on Growth Performance, Blood Cell Differential Count,and Blood Biochemical Measurements of Weaned Piglets after Lipopolysaccharide Challenge

The study was conducted to investigate the effect of aspartic acid(ASP) on growth performance,blood cell differential count,and blood biochemical measurements of weaned piglets after lipopolysaccharide(LPS) challenge.Twenty-four weaned piglets were randomly assigned into 4 groups:(1) control;(2) LPS;(3) LPS+0.5% ASP;(4) LPS+ 1.0% ASP.The results showed that 0.5% and 1.0% ASP alleviated the decrease of average daily gain induced by LPS challenge(P<0.05);After 3h,0.5% or 1.0% ASP significantly alleviated the decrease of lymphocyte proportion and platelet number,and the increase of eosinophil proportion induced by LPS challenge.0.5% ASP increased mean corpuscular hemoglobin(P<0.05).After 24 h,0.5% and 1.0% ASP significantly alleviated the increase of neutrophil number and proportion,the decrease of lymphocyte proportion(P <0.05).0.5% or 1.0% ASP significantly alleviated the increase of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,blood urea nitrogen,glucose,and the decrease of alanine aminotransferase / aspartate aminotransferase(P<0.05).These results suggest that ASP alleviated growth inhibition and stress response induced by LPS challenge.