Phosphorylated guanine nucleotide exchange factor C3G,induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton
(1) Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, 500 007, India
Abstract:
Background
The guanine nucleotide exchange factor C3G (RapGEF1) along with its effector proteins participates in signaling pathways that
regulate eukaryotic cell proliferation, adhesion, apoptosis and embryonic development. It activates Rap1, Rap2 and R-Ras members
of the Ras family of GTPases. C3G is activated upon phosphorylation at tyrosine 504 and therefore, determining the localization
of phosphorylated C3G would provide an insight into its site of action in the cellular context.