血管紧张素Ⅱ在针刺调整血压中的变化

<正> 临床与实验室工作已证明,针刺对血压具有双向性调整作用.针刺对休克或低血压状态,具有不同程度的升压作用;在高血压情况下,针刺又呈降压效应。关于这种双向性调整作用的途径与机理,既往文献多数为阐明神经作用的,至于体液因素仅涉及抗利尿素,肾上腺素和乙酰胆硷.

ALTERATION IN PLASMA ANGIOTENSIN Ⅱ CONTENTS IN THE REGULATING PROCESS OF ACUPUNCTURE ON ARTERIAL PRESSURE

There is evidence that renin-angiotensin system plays an important role in the maintenance of arterial pressure. Many investigators suggested that regulating effect of acupuncture on arterial pressure was significant in the situation of hypertension or hypotension. These experiments were designed to study the acupuncture effect on plasma angiotensin Ⅱ(AT-Ⅱ) level in 8 dogs with experimental hypertension or hypotension. Stimulation of the central end of femoral nerve dripping adrenalin into the vein, and removal of the carotid sinus nerves caused three types of experimental hypertension with a significant increase of plasma AT-Ⅱ. Acupuncture at the points Zusanli and Quchi produced a marked fall in arterial pressure and an accmpanying decrease of plasma AT-Ⅱ level (P<0.005). These results suggest that renin-angiotensin system plays an important role in the decrease of arterial pressure by acupuncture on hypertension To drip acetylcholine into the vein caused experimental hypotension with increase of plasma AT-Ⅱ contents. Acupuncture at the points Suliao, Renzhong and Neiguan produced a striking rise in arterial pressure with a marked fall in plasma AT-Ⅱ level; extending the carotid sinuses led to experimental hypotension with a decrease of plasma AT-Ⅱ contents. Acupuncture at the same points produced a striking rise in arterial pressure with a increase of plasma AT-Ⅱ contents; bleeding from artery gave rise to experimental hypotension with high plasma AT-Ⅱ level. Acupuncture at the same points produced a rise in arterial pressure, but did not induce any significant change in plasma AT-Ⅱ level. These results suggest that renin-angiotensin system plays a different role in the three types of hypotension. After the removal of renal nerves, acupuncture still has an action to decrease the arterial pressure in hypertension, and to increase the arterial pressure in hypotension. These results suggest that renin-angiotensin system plays an important role in regulating the process of acupuncture on arterial pressure, but it is not the only way of action.