骨形成蛋白4在胰腺癌组织中的表达及其临床意义初探

目的探讨胰腺癌组织中骨形成蛋白4（BMP4）的表达及其临床意义。方法应用免疫组化SP法检测42例胰腺癌组织、10例正常胰腺组织中BMP4的表达情况,并分析其与临床病理特征的关系。结果胰腺癌组织中BMP4的阳性表达率明显高于正常胰腺组织（χ2=13.90,P=0.01）。淋巴结转移组BMP4蛋白阳性表达率高于无淋巴结转移组（χ2=9.98,P=0.02）。Ⅲ期组BMP4蛋白阳性表达率高于Ⅰ＋Ⅱ期组（χ2=5.32,P=0.02）。结论在胰腺癌组织中BMP4高表达,且与肿瘤的浸润、转移有关。BMP4可以作为判断胰腺癌浸润、转移的参考指标之一。

Expression of BMP4 in pancreatic cancer and its clinical significance

Objective To investigate the expression of BMP4 in pancreatic carcinoma tissue and its clinical significance. Methods Expression of BMP4 was detected by immunohistochemistry SP method in 42 cases of pancreatic cancer and 10 normal pancreatic samples.Their association with clinical pathology was analyzed. Results The positive rate of BMP4 in the cancer tissue was significantly higher than that in the normal tissues （χ2=13.90,P=0.01） ,and the positive rate was also higher in the cases with lymph node metastasis than without （χ2=9.98,P=0. 02）. The rates of BMP4 expression in TNM stage Ⅲ was much higher than that in stage Ⅰ＋Ⅱ（χ2=5.32,P=0.02） Conclusion BMP4 is overexpressed in pancreatic cancer and is associated with the invasion and metastasis of the disease,the detection of it may be used as one of the parameters for judgement of the invasion and metastasis of this condition.