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Decreased inducibility of TNF expression in lipid-loaded macrophages |
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| Authors: | |
| Affiliation: | 1.Lund University, Wallenberg-laboratory,University Hospital MAS,Malm?,Sweden;2.Center for Molecular Medicine, Karolinska Hospital,Karolinska Institutet,Stockholm,Sweden;3.Nya Apodemus AB, Stockholm University, WGI,Arrenius Laboratory F3,Stockholm,Sweden |
| Abstract: | BackgroundInflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages. |
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