| 自拟补肾清心汤与结合雌激素片联用对围绝经期骨质疏松症患者骨密度与骨代谢标志物的影响 |
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| 引用本文： | 刘桂英,王雅红,闫亚男,冉淑玲,赵艳,张艳云,白丽英,梁娜.自拟补肾清心汤与结合雌激素片联用对围绝经期骨质疏松症患者骨密度与骨代谢标志物的影响[J].国际中医中药杂志,2019,41(4):357-360. |
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| 作者姓名： | 刘桂英 王雅红 闫亚男 冉淑玲 赵艳 张艳云 白丽英 梁娜 |
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| 作者单位： | 河北省唐山市丰润区第二人民医院妇产科 064000;河北省唐山市丰润区第二人民医院内三科 064000 |
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| 摘 要： | 目的探讨自拟补肾清心汤联合标准剂量结合雌激素片对女性围绝经期骨质疏松症(osteoporosis, OP)患者骨密度与骨代谢标志物的影响。方法将符合入选标准的160例OP患者采用随机数字表法分为2组,每组80例。对照组每日服用标准剂量的结合雌激素片,观察组在对照组基础上加服自拟补肾清心汤。2组均治疗12个月。采用ELISA法检测血清骨特异性碱性磷酸酶(bone-specific alkaline phosphatase, BALP)、Ⅰ型胶原C末端肽(C-terminal cross linked peptide, CTX-Ⅰ)、抗酒石酸酸性磷酸酶-5b(tartrate resistant acid phosphatase-5b, TRACP-5b)水平,采用双能X射线吸收测定法检测骨密度值,评价临床疗效。结果观察组总有效率为91.3%(73/80)、对照组为78.8%(63/80),2组比较差异有统计学意义(χ^2=3.971,P=0.046)。治疗后,观察组血清BALP水平(88.55±10.33)U/L比(80.47±8.67)U/L,t=5.399]高于对照组(P<0.01),CTX-Ⅰ(130.09±17.55)ng/ml比(164.71±19.45)ng/ml,t=11.928]、TRACP-5b(501.31±35.77)pg/L比(538.51±37.69)pg/L,t=6.498]水平低于对照组(P<0.01)。观察组治疗后腰椎L2~4骨密度值较同组治疗前升高(t=3.396,P=0.010)。结论自拟补肾清心汤与结合雌激素片联用可升高围绝经期OP患者的骨密度值与血清BALP水平,降低血清TRACP-5b、CTX-Ⅰ水平。
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| 关 键 词： | 骨质疏松 围绝经期 骨密度 骨代谢标志物 补肾清心汤 治疗 临床研究性 |
Bushen-Qingxin decoction combined conjugated estrogen tablets for perimenopausal women osteoporosis in patients with bone mineral density and bone metabolic markers |
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| Liu Guiying,Wang Yahong,Yan Yanan,Ran Shuling,Zhao Yan,Zhang Yanyun,Bai Liying,Liang Na.Bushen-Qingxin decoction combined conjugated estrogen tablets for perimenopausal women osteoporosis in patients with bone mineral density and bone metabolic markers[J].International Journal of Traditional Chinese Medicine,2019,41(4):357-360. |
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| Authors: | Liu Guiying Wang Yahong Yan Yanan Ran Shuling Zhao Yan Zhang Yanyun Bai Liying Liang Na |
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| Affiliation: | (Department of Obstetrics and Gynecology,Second People Hospital of Fengrun District,Tangshan 064000,China) |
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| Abstract: | Liu Guiying;Wang Yahong;Yan Yanan;Ran Shuling;Zhao Yan;Zhang Yanyun;Bai Liying;Liang Na(Department of Obstetrics and Gynecology,Second People Hospital of Fengrun District,Tangshan 064000,China) |
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| Keywords: | Osteoporosis Perimenopause Bone density Bone metabolic markers Bushen-Qingxin decoction Therapies investigational |
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