首发抑郁症伴自杀意念患者大脑功能连接时间动力学改变

目的 观察伴自杀意念（SI）首发抑郁症患者大脑功能连接（FC）的时间动力学改变。方法 前瞻性纳入57例首发抑郁症伴SI患者（SI组）、42例首发抑郁症不伴SI患者（NSI组）及48名健康志愿者（HC组），行脑功能MRI和抑郁症相关量表评估；根据FC密度（FCD）标准差量化整个大脑、大脑半球间及半球内动态FCD （dFCD）的时间变异性，分析FC时间动力学改变。结果 SI组汉密尔顿抑郁量表24项（HAMD-24）总分大于NSI组（P<0.05）。SI组左侧颞中回的全脑dFCD方差值高于NSI组和HC组（P均<0.05），SI组右侧颞中回半球内dFCD方差值高于HC组（P<0.05），而SI组和NSI组右侧额中回/额下回半球间dFCD方差值均低于HC组（P均<0.05）。结论 首发抑郁症伴SI患者额、颞叶FC存在动态改变。

Temporal dynamics changes of brain functional connectivity in first-episode depression patients with suicidal ideation

Objective To observe the temporal dynamics changes of brain functional connectivity (FC) in first-episode depression patients with suicidal ideation (SI). Methods A total of 57 first-episode depression patients with SI (SI group), 42 first-episode depression patients without SI (NSI group) and 48 healthy volunteers (HC group) were prospectively enrolled. Brain functional MRI and depression related scale evaluation were performed, the time variability of global, inter- and intra-hemispheric dynamic FC density (dFCD) were quantified based on the standard deviation of FC density (FCD), and the temporal dynamics changes of brain FC were analyzed. Results The total score of Hamilton depression scale 24-items (HAMD-24) of SI group was higher than that of NSI group (P<0.05). The global dFCD variance of left middle temporal gyrus in SI group was higher than that in NSI group and HC group (both P<0.05), of right middle temporal gyrus in SI group was higher than that in HC group (P<0.05). The intra-hemispheric dFCD variance of right middle temporal gyrus/inferior frontal gyrus in SI group and NSI group were lower than those in HC group (both P<0.05). Conclusion FC of frontal and temporal lobes dynamicly changed in first-episode depression patients with SI.