| 缓释微丸及血浆中酮洛芬的HPLC测定 |
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| 引用本文： | 葛庆华,张焱.缓释微丸及血浆中酮洛芬的HPLC测定[J].中国医药工业杂志,1994,25(11):505-507. |
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| 作者姓名： | 葛庆华 张焱 |
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| 作者单位： | 上海医药工业研究院 |
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| 摘 要： | 采用国产ＯＤＳ柱，用０．０５ｍｏｌ／ＬＫＨ＿２ＰＯ＿４－甲醇（４５：５５）为流动相，以波长２６０ｎｍ检测缓释微丸中的酮洛芬（１）含量。采用无水乙醇一次萃取血浆样品中的１，以ｐＨ８．０的磷酸盐缓冲液溶解残渣后测定，平均回收率为９１．４％。
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| 关 键 词： | 酮洛芬，高效液相色谱法，测定 |
HPLC FOR ASSAY OF KETOPROFEN IN SUSTAINED RELEASE PELLETS AND PLASMA |
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| Authors: | GE Qing-Hua ZHANG Yan CHEN Qing-Hua |
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| Abstract: | An ODS column, with 0.05mol/L KH2PO4-methanol (45:55) as the mobile phase, 260nm as detection wavelength was used to assay ketoprofen(1) in sustained release pellets. With this improved HPLC method,the blood concentration of 1 was determined by extracting 1 from plasma with ethanol,and after the evaporation of solvent, the residue was taken in pH 8.0 phosphate buffer.The recovery of the drug was 91.4%. |
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| Keywords: | ketoprofen HPLC determinatioa |
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