An oxepinoflavone from <Emphasis Type="Italic">Artocarpus elasticus</Emphasis> with cytotoxic activity against P-388 cells |
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| Authors: | Iqbal Musthapa Lia D Juliawaty Yana M Syah Euis H Hakim Jalifah Latip Emilio L Ghisalberti |
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| Affiliation: | (1) Institut Teknologi Bandung, Natural Products Research Group, Faculty of Mathematics and Natural Sciences, Jalan Ganesha 10, Bandung, 40132, Indonesia;(2) School of Chemistry and Food Technology, Faculty of Science and Technology, National University of Malaysia, 43600 Bangi, Selangor, Malaysia;(3) Chemistry, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, Crawley, WA, 6009, Australia |
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| Abstract: | A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia
P-388 cells, the new compound showed IC50 5.0 μg/mL. |
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| Keywords: | Artocarpus elasticus Flavonoids Oxepinoflavone Artoindonesianin E1 Cytotoxicity P-388 cells |
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