| RP-HPLC法测定青蒿琥酯阿莫地喹片中主药的含量 |
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| 引用本文： | 胡志强,蒋锋,姚忠.RP-HPLC法测定青蒿琥酯阿莫地喹片中主药的含量[J].淮海工学院学报,2014(2):59-61. |
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| 作者姓名： | 胡志强 蒋锋 姚忠 |
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| 作者单位： | [1]宜兴市人民医院,江苏宜兴214200 [2]江苏鹏鹞药业有限公司,江苏宜兴214200 |
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| 摘 要： | 建立RP-HPLC法测定青蒿琥酯阿莫地喹片中主药的含量。色谱柱为安捷伦的C18柱(4.6mm×15cm),测定青蒿琥酯的流动相为乙腈—磷酸盐缓冲液,检测波长为210nm,测定阿莫地喹的流动相为甲醇—磷酸盐缓冲液,检测波长为224nm。在考察青蒿琥酯(0.500 5~2.002mg/mL)和阿莫地喹(25.03~100.1μg/mL)的质量浓度范围内具有良好的线性关系,r均达到0.999,平均回收率分别为98.6%和99.5%。结果表明,两套分析方法测定主药的含量,结果准确、可靠。
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| 关 键 词： | 青蒿琥酯阿莫地喹片 RP-HPLC 青蒿琥酯 阿莫地喹 |
Determination of Artesunate and Amodiaquine Hydrochloride Tablets by RP-HPLC |
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| HU Zhi-qiang,JIANG Feng,YAO Zhong.Determination of Artesunate and Amodiaquine Hydrochloride Tablets by RP-HPLC[J].Journal of Huaihai Institute of Technology:Natural Sciences Edition,2014(2):59-61. |
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| Authors: | HU Zhi-qiang JIANG Feng YAO Zhong |
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| Affiliation: | 1. Yixing People＇ s Hospital, Yixing 214200, China; 2. Jiangsu Pengyao Pharmaceutical Co. , Ltd. , Yixing 214200, China) |
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| Abstract: | A method for the determination of artesunate and amodiaquine hydrochloride tablets by RP-HPLC was established.The agilent C18（4.6 mm×15 cm）column was used,and the detection wavelength of artesunate was 210 nm.The mobile phase of artesunate was acetonitrile and the buffer solution.The detection wavelength of amodiaquine hydrochloride was 224 nm.The mobile phase of amodiaquine hydrochloride was methanol：phosphate buffer.The linear ranges of artesunate （0.500 5-2.002 mg/mL）and amodiaquine hydrochloride （25.03-100.1μg/mL）were good （r=0.999）with the average recovery rates of 98.6%and 99.5%.The method is simple and accurate,and it can be used for the determination of artesunate and amodiaquine hydrochloride tablets. |
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| Keywords: | artesunate and smodiaquine hydrochloride tablets RP-HPLC artesunate amodiaquine hydrochloride |
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