| 尖山橙和龙州山橙中的抗肿瘤吲哚生物碱(英文) |
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| 引用本文： | 蔡祥海,蒋皓,李艳,程桂广,刘亚平,冯涛,罗晓东.尖山橙和龙州山橙中的抗肿瘤吲哚生物碱(英文)[J].中国天然药物,2011(4):259-263. |
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| 作者姓名： | 蔡祥海 蒋皓 李艳 程桂广 刘亚平 冯涛 罗晓东 |
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| 作者单位： | 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.21072198); the West Light Foundaton of the Chinese Academy of Sciences(No.KSCX2-YW-EW-15)~~ |
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| 摘 要： | 目的:研究尖山橙和龙州山橙中的抗肿瘤生物碱成分方法:采用层析柱和制备高效液相进行化合物分离,运用1D、2D-NMR及MS等波谱分析技术鉴定化合物结构。采用MTT法进行人体肿瘤细胞毒体外活性实验。结果:分离得到两个新的双吲哚生物碱melofusine I (1)和melomorsine I (2),以及22个已知吲哚生物碱,测试了24个化合物对5种(SW480,SMMC-7721,HL-60,MCF-7,A-549)人体肿瘤细胞的细胞毒活性。结论:化合物1-2是新的双吲哚生物碱,化合物tabersonine(3) and 19S-vindolinine(14)具有抑制5种人体肿瘤细胞株的活性。
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| 关 键 词： | 尖山橙 龙州山橙 Melofusine I Melomorsine I 双吲哚生物碱 细胞毒活性 |
Cytotoxic Indole Alkaloids from Melodinus fusiformis and M.morsei |
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| CAI Xiang-Hai,JIANG Hao,LI Yan,CHENG Gui-Guang,LIU Ya-Ping,FENG Tao,LUO Xiao-Dong Laboratory of Phytochemistry , Plant Resources in West China,Kunming Institute of Botany,the Chinese Academy of Kunming ,China.Cytotoxic Indole Alkaloids from Melodinus fusiformis and M.morsei[J].Chinese JOurnal of Natural Medicines,2011(4):259-263. |
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| Authors: | CAI Xiang-Hai JIANG Hao LI Yan CHENG Gui-Guang LIU Ya-Ping FENG Tao LUO Xiao-Dong Laboratory of Phytochemistry Plant Resources in West China Kunming Institute of Botany the Chinese Academy of Kunming China |
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| Affiliation: | CAI Xiang-Hai,JIANG Hao,LI Yan,CHENG Gui-Guang,LIU Ya-Ping,FENG Tao,LUO Xiao-Dong* Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,the Chinese Academy of Kunming 650204,China |
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| Abstract: | AIM:To investigate antitumor indole alkaloids from the leaves and twigs of Melodinus fusiformis and M.morsei.METHODS:The indole alkaloids were isolated by column chromatography and preparative HPLC.Their structures were elucidated by 1D and 2D-NMR spectroscopic methods in combination with MS experiments.Their cytotoxicity were evaluated using the MTT method in 96-well microplates.RESULTS:Two new bisindole alkaloids,melofusine I(1) and melomorsine I(2),together with 22 known indole alkaloids 3-24,were isolat... |
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| Keywords: | Melodinus fusiformi M morsei Melofusine I Melomorsine I Bisindole alkaloids Cytotoxicity |
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