糖耐量减低患者桡动脉增强指数影响因素分析

目的分析糖耐量减低(IGT)患者桡动脉反射波增强指数(rAI)的主要影响因素。方法选取北京地区参加健康调查的IGT患者600例,年龄26～90岁,平均(58.7±12.6)岁,其中男性227人,女性373人。检测身高、体质量、心率、体质量指数、腰围、血压、总胆固醇、三酰甘油、LDL-C、HDL-C、空腹血糖、餐后2h血糖等指标,采用科林HEM-9000AI自动检测仪检测左侧桡动脉rAI,采用SPSS16.0软件分析IGT患者rAI的影响因素。结果在单因素相关分析中,IGT患者rAI与年龄、腰围、收缩压、脉压、平均动脉压、HDL-C呈正相关,与身高、体质量、心率、空腹血糖呈负相关。女性rAI均高于男性。多元回归分析显示,IGT患者rAI与性别(β=0.27,P<0.01)、年龄(β=0.16,P<0.01)、身高(β=-0.12,P<0.05)、心率(β=-0.47,P<0.01)和平均动脉压(β=0.19,P<0.01)独立相关。结论性别、年龄、身高、心率和平均动脉压是IGT患者rAI的独立影响因素,采用rAI评估动脉僵硬度时要综合考虑上述因素的影响。

Determinant factors of radial augmentation index in patients with impaired glucose tolerance

Objective The radial augmentation index（rAI）is a useful index of aortic stiffness.To study the determinants of radial augmentation index in subjects with impaired glucose tolerance（IGT）.Methods In the present study,600 IGT subjects（227 men and 373 women）of Beijing aged 26-90 years（58.7±12.6years）were enrolled,Height,weight,heart rate,BMI,waistline,blood pressure,total cholesterol,triglycerides,HDL-C,LDL-C,fasting glucose and OGTT2h glucose were measured.The rAI were measured in the left radial artery using tonometry Colin HEM-9000AI.Statistical analysis were performed using SPSS 16.0.Results rAI of patients with IGT showed a positive relationship with age,waistline,SBP,PP,MBP,HDL-C and a negative association with height,weight,HR and fasting glucose,women had significantly higher rAI than men.Stepwise regression analysis revealed that sex（β=0.27,P0.01）,age（β=0.16,P0.01）,height（β=-0.12,P0.05）,HR（β=-0.47,P0.01）and MBP（β=0.19,P0.01）were independent determinants of rAI in subjects with IGT.Conclusions Sex,age,height,HR and MBP are independent determinants of rAI in subjects with IGT.It is necessary to take into account these confounding factors when rAI is used as an index for aortic stiffness to IGT.