| 帕罗西汀对卒中后抑郁病人的功能恢复作用 |
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| 引用本文： | 陈伟,王根发,陈兴华,盛永亮,朱弘.帕罗西汀对卒中后抑郁病人的功能恢复作用[J].中国组织工程研究与临床康复,2002,6(13):2014-2015. |
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| 作者姓名： | 陈伟 王根发 陈兴华 盛永亮 朱弘 |
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| 作者单位： | Xinhua Hospital，Shanghai Second Medical University，Shanghai 200092，China |
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| 摘 要： | Depressionisthecommoncomplicationofstroke，whichoccursinatleast３０％ofthestrokepatients．Depressionaffectsthepatients＇rehabilitationsignificantly．Itiscommonlyadmittedthat５－HTreup－takeinhibitorshavegoodeffectontreatingpoststrokedepression（PSD）．Thispaperstudiestheclinicaltherapeuticeffectofparoxetineoneofthe５－HTreuptakeinhibitorsintreatingPSDanditseffectonthepatients＇nervefunctions．Comparedwiththetricircularantide－pressionreagents，suchasdoxepin，themechanismofthetherapeuticeff…
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Effects of paroxetine on function recovery in patients with poststroke depression |
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| Abstract: | Objective To evaluate the effects of the selective serotonin reuptake inhibitor(SSRI) paroxetine on the functional capacities of poststroke depression.Method Seventy five patients were randomly assigned to 3 groups,during 8 weeks of therapy,patients were treated wtih paroxetine,doxepin, and placebo.Before and at the end of the observation,we assessed ADL by Barthel index,degree of neurological deficit by Chinese stroke scale and depressive symptomatology by Hamilton depression rating scale.Results The three groups ameliorated ADL capacities and neurological deficitto different extents.The greatest improvement was observed in the paroxetine treated group.Conclusion Paroxetine may facilitate recovery in patients with poststroke depression undergoing rehabilitation.The effects of SSRI as an adunct to physical therapy warrant further investigation. |
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| Keywords: | poststroke depression rehabilitation paroxetine |
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