基于“癌毒”的肿瘤发生发展规律探讨

通过对"癌毒"相关文献的客观整理,从癌毒的性质、致病特点及其与正虚的辨证关系等方面,探讨肿瘤发生发展的客观规律。认为癌毒的性质主要包括易伤正气、其性沉伏、发病猛烈、其性善行、易与痰瘀凝结等几个方面;邪毒内结导致肿瘤的发生,癌毒流散引发肿瘤的侵袭与转移;与此同时,肿瘤的发生与机体的正气也有着密不可分的关系,患者的气血阴阳虚弱、脏腑功能失调是癌毒发生、发展的必要条件。根据癌毒的性质及致病特点,归纳出癌症各个阶段的治疗原则,采用扶正与祛邪相结合的方法,调整阴阳平衡,从而达到治疗肿瘤的目的。

Discriminant analysis of both yin and yang deficiency syndrome in 350 patients with type 2 diabetic nephropathy

Objective: To develop an objective assessment of both yin and yang deficiency syndrome in patients with diabetic nephropathy(DN).Methods: A cross-sectional survey was performed,and a total of 350 patients with type 2 diabetic nephropathy stage Ⅲ,Ⅳ or Ⅴfrom 8 centers were enrolled in this survey.The distribution of both yin and yang deficiency syndrome in DN was described,and the clinical parameters were compared between both yin and yang deficiency syndrome and the others.At last,discriminant analysis was used for the objective assessment of both yin and yang deficiency syndrome.Result: In all the 350 patients,the proportion of 208 cases with both yin and yang deficiency syndrome was 59%.From stage Ⅲ to Ⅴ,there was an increased proportion with a statistic significance(P<0.05) in each stage,which were 34%,62%,and 86% respectively.In addition,there were 7 parameters with statistic differences between both yin and yang deficiency and the others,including diabetes duration,systolic pressure,hemoglobin,glycated hemoglobin,24-hour urine protein,serum creatinine and urea nitrogen(P<0.05).The equations were built for the assessment of both yin and yang deficiency by Bayes discriminant analysis.The error rates tested by backtracking and jackknife methods were both 19.71%.Conclusion: Disciminant analysis of clinical parameters associated with DN could be useful for the objective assessment of both yin and yang deficiency syndrome.