沙库巴曲缬沙坦对扩张型心肌病心力衰竭患者心肌损伤、左室功能及运动耐量的影响

目的 观察沙库巴曲缬沙坦对扩张型心肌病心力衰竭患者心肌损伤、左室功能及运动耐量的影响.方法 随机双盲选择我院收治的120例扩张型心肌病心力衰竭患者作为研究对象,按随机数字表法将其分为对照组和观察组,各60例.对照组采用常规抗心力衰竭方案治疗,观察组在常规方案基础上给予沙库巴曲缬沙坦治疗.比较两组的治疗效果.结果 治疗后,两组的心肌损伤指标(NT-proBNP、cTnI、sICAM-1、CgA)、左室功能指标(LVEF、LVEDV、LVESV、LAD)、运动耐量指标(6MWT、运动时间、运动代谢当量)均显著改善,且观察组优于对照组(P<0.05).结论 沙库巴曲缬沙坦应用于扩张型心肌病心力衰竭患者中可减轻其心肌损伤,改善左室功能,提高运动耐量,值得临床推广.

Effects of sacubitril valsartan on myocardial injury,left ventricular function and exercise tolerance in patients with dilated cardiomyopathy and heart failure

Objective To observe the effects of sacubitril valsartan on myocardial injury,left ventricular function and exercise tolerance in patients with dilated cardiomyopathy and heart failure.Methods A total of 120 patients with dilated cardiomyopathy and heart failure treated in our hospital were randomly and double-blind selected as the research objects.The patients were divided into control group and observation group according to random number table method,with 60 cases in each group.The control group was treated with conventional anti-heart failure scheme,and the observation group was treated with sacubitril valsartan on the basis of conventional regimen.The therapeutic effects were compared between the two groups.Results After treatment,the indexes of myocardial injury(NT-proBNP,cTnI,sICAM-1,CgA),left ventricular function(LVEF,LVEDV,LVESV,LAD)and exercise tolerance(6MWT,exercise time,exercise metabolic equivalent)of the two groups significantly improved,and those of the observation group were better than the control group(P<0.05).Conclusion Sacubitril valsartan applied in patients with dilated cardiomyopathy and heart failure can reduce myocardial injury,improve left ventricular function and exercise tolerance,which is worthy of clinical promotion.