共处理制备直接压片辅料的研究现况

直接压片法是片剂生产的首选方法，受粉体流动性、可压性、稀释潜力等性质的影响较大。应用粉体工程学，通过共处理法将单一辅料在颗粒水平上相结合制备的共处理辅料能满足直接压片片剂生产过程对辅料的要求。作者简要介绍了直接压片法的优势、共处理辅料的研究对象、共处理方法，对现有市售共处理辅料进行归纳整理，结合实验室相关研究，展望共处理辅料的应用前景。

Research Situation of Direct Compression Excipients via Co-processing

Direct compression process was the preferred method for preparation of tablets,but itwas highly influenced by powder characteristics such as flowability,compressibility,dilution potential and so on.Demands of excipients in direct compression process could be satisfied by powder engineering with co-processing of single excipient in particles level.This review briefly introduced advantages of direct compression process,choosing object of co-processed excipients and co-processing methods,some of market available co-processed excipients were concluded and analyzed,and combined with laboratory research,application prospect of co-processed excipients was discussed.