| 亚甲基四氢叶酸还原酶基因多态和叶酸摄取与乳腺癌的发病风险 |
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| 引用本文： | 高长明,唐金海,曹海霞,丁建华,吴建中,王洁,刘燕婷,李苏平,苏平.亚甲基四氢叶酸还原酶基因多态和叶酸摄取与乳腺癌的发病风险[J].中华预防医学杂志,2004,43(1):576-580. |
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| 作者姓名： | 高长明 唐金海 曹海霞 丁建华 吴建中 王洁 刘燕婷 李苏平 苏平 |
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| 作者单位： | 江苏省肿瘤防治研究所流行病审,南京,210009;Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Japan;Department of Internatianal Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan; |
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| 基金项目： | 日本文部科技运动省国际科学研究癌症特别研究项目江苏省科技厅社会发展重大项目 |
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| 摘 要： | Objective To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5, 10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk. Methods A case-control study was conducted with 669 cases and 682 population-based controls in Jiangsu province of China. MTHFR C677T and AI298C genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods. Dietary folate intake was assessed by using an 83-item food frequency questionnaire. Odds ratios (OR) were estimated with an unconditional logistic model. Results The frequencies of MTHFR C677T C/C, C/T and T/T genotypes were 32. 37% (202/624), 48. 88% (3051624) and 18. 75% (117/624) in cases and 37. 66% (235/624), 48.24% (301/624) and 14. 10% (88/624) in controls,respectively. The difference in distribution was significant (X2=6. 616, P=0. 037), the T/T genotype being associated with an elevated OR for breast cancer (1.62, 95% CI: 1.14 -2. 30). The frequencies of MTHFR A1298C A/A,A/C and C/C were 71.47% (446/624), 27.08% (169/624) and 1.44% (9/624) in cases and 68. 11% (425/624) ,30. 13% (188/624) and 1.76% (11/624) in controls, with no significant differences found (X2=1.716, P=0. 424). Folate intake of cases (263.00±137. 38)μg/d]was significantly lower than that of controls (285. 12±149. 61)μg/d](t=-2. 830,P=0. 005). Compared with the lowest tertile (≤199. 08μg/d) of folate intake,the adjusted OR for breast cancer in the top tertile (≥315.μg/d) was 0. 70 (95% CI:0. 53 -0. 92). Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0. 89 (95% CI: 0. 62 -1.27)and 1.69 (95% CI: 1.20 -2. 36) for the second to the third tertite of folato intake compared with thehighest folate intake group (Xtrend2=11. 372, P=0. 001). Conclusion The findings of the present study suggest that MTHFR genetic polymorphisms, and dietary intake of folate may modify susceptibility to breast cancer.
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| 关 键 词： | 乳腺肿瘤 亚甲基四氢叶酸还原酶 多态现象 遗传 叶酸 |
MTHFR polymorphisms,dietary folate intake and risks to breast cancer |
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| Kazuo Ta-jima,Keitaro Matsuo,Toshim Takezaki,CAO Chang-ming,Kazuo Ta-jima,TANG Jin-hai,CAO Hai-xia,DING Jian-hua,WU Jian-zhong,WANG Jie,LIU Yan-ting,LI Su-ping,SU Ping,Keitaro Matsuo,Toshim Takezaki.MTHFR polymorphisms,dietary folate intake and risks to breast cancer[J].Chinese Journal of Preventive Medicine,2004,43(1):576-580. |
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| Authors: | Kazuo Ta-jima Keitaro Matsuo Toshim Takezaki CAO Chang-ming Kazuo Ta-jima TANG Jin-hai CAO Hai-xia DING Jian-hua WU Jian-zhong WANG Jie LIU Yan-ting LI Su-ping SU Ping Keitaro Matsuo Toshim Takezaki |
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| Abstract: | |
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| Keywords: | Breast neoplasmsMethylenetetrahydrofolate reductasePolymorphisms geneticFolic acid |
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