孟鲁司特钠治疗儿童腹型过敏性紫癜的临床观察

目的:探讨孟鲁司特钠在腹型过敏性紫癜患儿中的应用效果。方法:选取2012年3月至2015年7月于我院接受治疗的84例腹型过敏性紫癜患儿,按照随机数表法分为试验组和对照组各42例。对照组患儿给予常规治疗加丙种球蛋白,试验组患儿在对照组的基础上联合孟鲁司特钠咀嚼片进行治疗。记录两组患儿的临床疗效及复发情况,对两组患儿腹痛、血便、皮疹消退情况、呕吐情况等进行比较分析。结果:试验组皮疹消退时间短于对照组,差异有统计学意义(P<0.05)。试验组患儿腹痛缓解时间、呕吐缓解时间、血便消失时间分别为(2.8±0.7)d、(3.4±2.1)d、(4.8±0.6)d,对照组患儿腹痛缓解时间、呕吐缓解时间、血便消失时间分别为(5.5±1.7)d、(6.0±2.6)d、(10.1±1.3)d,两组比较差异均有统计学意义(P均<0.05)。治疗后3个月,试验组无复发,对照组复发4例(9.5%),差异有统计学意义(P<0.05);治疗后6个月,试验组复发2例(4.8%),对照组复发9例(21.4%),差异有统计学意义(P<0.05)。结论:孟鲁司特钠应用于腹型过敏性紫癜患儿可有效缓解症状,见效迅速,复发率较低。

Montelukast Sodium in Children with Abdominal Allergic Purpura

Objective: To explore the application effect of montelukast sodium in children with abdominal allergic purpura. Methods: Eighty-four cases of abdominal type allergic purpura were selected from March 2012 to July 2015 in our hospital, randomly divided into two groups, experimental group and control group of 42 cases. The control group was treated with conventional therapy and gamma globulin, the experimental group on the basis of conventional therapy combined with treatment of montelukast sodium chewable tablets. The clinical efficacy and recurrence of two groups were recorded, abdominal pain, bloody diarrhea, rash subsided, vomiting of the two groups were statistically analyzed. Results: The time of rash subsided in the experimental group was significantly shorter than that in the control group, and the difference between the two groups was statistically significant (P<0.05). The symptoms of abdominal pain relief time of the experimental group was (2.8±0.7)d, the control group was (5.5±1.7)d, vomiting remission time in experimental group was (3.4±2.1)d, the control group was (6.0±2.6)d, bloody diarrhea disappearance time of experimental group was (4.8±0.6) d, the control group was (10.1±1.3) d. Comparison of two groups of children with disease recurrence, the experimental group of children within 6 months of recurrence in 2 cases, the control group of children with recurrence of 9 cases, there was significant difference between the two groups (P<0.05). Conclusion: Montelukast sodium in the application of abdominal allergic purpura can effectively relieve symptoms with quick effect and low recurrence rate.