| 几种新透明质酸金属配合物的合成及生物活性 |
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| 引用本文： | 朱湛,王亚利,杨艳萍,许施卓,窦晶晶,郭炳南.几种新透明质酸金属配合物的合成及生物活性[J].北京理工大学学报,2012,32(11):1200-1204. |
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| 作者姓名： | 朱湛 王亚利 杨艳萍 许施卓 窦晶晶 郭炳南 |
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| 作者单位： | 北京理工大学原子分子簇科学教育部重点实验室,北京,100081;北京理工大学原子分子簇科学教育部重点实验室,北京,100081;北京理工大学原子分子簇科学教育部重点实验室,北京,100081;北京理工大学原子分子簇科学教育部重点实验室,北京,100081;北京理工大学原子分子簇科学教育部重点实验室,北京,100081;北京理工大学原子分子簇科学教育部重点实验室,北京,100081 |
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| 基金项目： | 国家自然科学基金资助项目(20871017) |
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| 摘 要： | 以质酸钠为原料,合成了多种质酸金属配合物,质酸镁、质酸镓、质酸镧、质酸铈、质酸钕.所合成的目标化合物经过IR,1 HNMR,EDX和元素分析表征,并在体外通过MTT法,实验了几种质酸金属配合物对子宫颈癌细胞的生物活性.结果表明:几种质酸金属配合物对子宫颈癌细胞的增殖与本底质酸钠相比有较好的抑制作用.
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| 关 键 词： | 质酸 质酸金属配合物 子宫颈癌 |
| 收稿时间： | 2011/11/14 0:00:00 |
Synthesis of New Hyaluronic Metal Complexes and Investigation of Biological Activity |
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| ZHU Zhan,WANG Ya-li,YANG Yan-ping,XU Shi-zhuo,DOU Jing-jing and GUO Bing-nan.Synthesis of New Hyaluronic Metal Complexes and Investigation of Biological Activity[J].Journal of Beijing Institute of Technology(Natural Science Edition),2012,32(11):1200-1204. |
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| Authors: | ZHU Zhan WANG Ya-li YANG Yan-ping XU Shi-zhuo DOU Jing-jing and GUO Bing-nan |
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| Affiliation: | Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science of Ministry of Education, Beijing Institute of Technology, Beijing 100081, China |
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| Abstract: | Several new hyaluronic metal complexes were synthesized with the sodium hyaluronate as raw material. The properties of synthesized complexes were characterized by IR, 1HNMR, EDX and elemental analysis. The preliminaries of anticancer activities in vitro on human uterine cancer cells demonstrate that a few of new hyaluronic metal complexes have better anticancer activity than that of the background sodium hyaluronate. |
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| Keywords: | sodium hyaluronate hyaluronic metal complexes uterine cancer |
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