1,5-双(5-溴水杨醛)缩二氨基硫脲二丁基锡配合物的合成,晶体结构和杀菌活性研究

利用1,5-双(5-溴水杨醛)缩二氨基硫脲席夫碱与二丁基氧化锡为原料,在苯-甲苯混合溶剂中回流反应合成了一种新的有机锡席夫碱配合物,分子式为C23H18Br2N4O2SSn,用元素分析、红外光谱、核磁共振谱对目标化合物结构进行了表征,并用X-射线单晶衍射对其结构进行了确证.晶体结构解析表明,标题配合物的晶体属单斜晶系,P21/c空间群,每个独立单元中含有两个分子结构单元,晶胞参数:a=17.9191(9)(A),b=18.791(1)(A),c=17.9453(9)(A),a=115.447(1)埃琕=5456.2(5)(A)3,Z=4,Dcalc=1.709g/cm3.分子间经典的N-H…N氢键使分子相互结合形成了二聚体,后者再通过范德华作用力结合堆积形成完成的晶体结构.抑菌活性测定结果表明,标题化合物及其类似物的抑菌活性具有较大的选择性,对苏云金杆菌(B.thuringiensis)和枯草杆菌(B.Subtilis)的抑菌能力较高,而对大肠杆菌(E.Coli)和金黄色葡萄球菌(S.Aureus)的抑菌能力较低.

Synthesis, crystal structure and antimicrobial activities of dibutyltin(Ⅳ) complex of 1,5-bis(5-bromo-2-hydroxybenzylidene)thiocarbohydrazide

The title compound (Ⅰ),dibutyltin(Ⅳ) complex of 1，5-bis (5-bromo-2-hydroxybenzylidene) thiocarbohydrazide,molecular formula C23H28Br2N4O2SSn,was synthesized by the reaction of 1,5-bis(5-bromo-2-hydroxy-benzylidene) thiocarbohydrazide with dibutyltin oxide in refluxing benzene-toluene,and its structure was characterized by elemental analysis, IR and IH NMR spectroscopy. The crystal structure of the title complex has been determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/c with a=17.9191(9)(A),b=18.791(1)(A),c=17.9453(9)(A),a=115.447(1)Dcalc=1.709g/cm3. The strong intermolecular N-H…N hydrogen bonds lead to the formation of dimer,and all the dimer are held together by the van der Waals force. The antimicrobial test shows that the title compound and its analogue possess high antimicrobial activities against B. thuringiensis and B. Subtilis,and slightly less active against E.Coli and S.Aureus.