| 淋巴细胞凋亡异常在AITP患儿中的作用研究 |
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| 引用本文： | 孟瑞锋,盛光耀,王利.淋巴细胞凋亡异常在AITP患儿中的作用研究[J].医药论坛杂志,2006,27(14):37-38,41. |
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| 作者姓名： | 孟瑞锋 盛光耀 王利 |
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| 作者单位： | 郑州大学第一附属医院儿科,郑州市,450052 |
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| 摘 要： | 目的 探讨急性特发性血小板减少性紫癜（AITP）患儿外周血淋巴细胞凋亡情况及凋亡蛋白Bcl-2和Bax蛋白表达情况.方法 采AITP患儿外周血,分离淋巴细胞,用原位细胞凋亡方法检测淋巴细胞凋亡率,用免疫组化法检测淋巴细胞Bcl-2及Bax蛋白表达率.结果 AITP患儿治疗前可见少量凋亡淋巴细胞,正常对照组未见明显凋亡细胞,Bcl-2蛋白表达率较正常对照组明显升高,Bax蛋白表达率较正常对照组降低.结论 淋巴细胞凋亡异常在AITP发病机制中起重要作用.
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| 关 键 词： | 特发性血小板减少性紫癜 凋亡 Bcl-2蛋白 Bax蛋白 |
| 文章编号： | 1672-3422（2006）14-0037-03 |
| 收稿时间： | 04 1 2006 12:00AM |
| 修稿时间： | 2006-04-01 |
The Role of Abnormal Apoptosis of Lymphocytes in Idiopathic Thrombocytopenic Purura |
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| MENG Rifeng,SHENG Guangyao,WANG Li.The Role of Abnormal Apoptosis of Lymphocytes in Idiopathic Thrombocytopenic Purura[J].Journal of Medical Forum,2006,27(14):37-38,41. |
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| Authors: | MENG Rifeng SHENG Guangyao WANG Li |
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| Affiliation: | The First Affliated Hospital of Zhengzhou University, Zhengzhou 450052, China |
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| Abstract: | Objective To investigate lymphocytes apoptosis,Bcl-2 protein and Bax protein expression in children with acute idiopathic thrombocytopenic purura(AITP).Methods The blood samples were collected in children with AITP before treatment,in situ cell apoptosis(TUNEL method),Bcl-2 protein and Bax protein expression(immunohistochemical method) were detected.Results There are a sprinkle of apoptotic lymphocytes in children with AITP before treatment,while there are few apoptotic lymphocytes in the controls.The rate of Bcl-2 protein expression before treatment is increased,the rate of Bax protein expression is decreased.Conclusion The abnormal lymphocytes apoptosis in children with AITP might play an important role in its pathogenesis. |
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| Keywords: | Idiopathic thrombocytopenic purura Apoptosis Bcl - 2 protein Bax protein |
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