黄蜀葵花总黄酮镇痛作用研究

目的：研究黄蜀葵花总黄酮（Total Flavone of Abelmoschl manihot L medic TFA)的镇痛作用及有无成瘾性。方法：采用冰醋酸致小鼠扭体模型（AA）、福尔马林模型（For)及KCl诱痛模型来观察TFA的镇痛作用；采用连续给药方式观其作用有无成瘾性。结果：TFA（ig或ip）可不同程度地抑制小鼠扭体反应；TFA（140、280mg/kg，ig)可使福尔马林致小鼠疼痛的Ⅰ、Ⅱ相反应明显减轻，TFA（ip1)对同侧ip1福尔马林导致的疼痛可产产生同样抑制作用，但对侧ip1福尔马林致小鼠疼痛无明显影响，动脉注射TFA200mg/kg可明显减轻KCl诱发的家兔疼痛反应，连续用药可使TFA在小鼠跳跃实验中，阳性率为0。结论：以上研究结果表明TFA具有一定的镇痛作用且局部给药有效，连续用药无成瘾性。

Analgesic effect of Total Flavone of Abelmoschl manihot L medic

Objective: To observe the analgesic effect of Total flavone of Abelmoschl Manihot L medic (TFA) and also to inspect when TFA was administered repeatedly and regularly, whether it would cause addiction. Methods: Several classical models, such as acetic acid writhing test (AA), formalin pain test (For), KCl test, etc were adopted to observe the analgesic effect of TFA. In addition, addiction was observed via administration of TFA repeatedly and regularly. Results: TFA (ig or ip) can significantly reduce the writhing number in mice; TFA (140?280mg/kg, ig) can obviously shortening the paw licking time both in phase I and phase II in the For pain test; the same effect was produced while ip1 TFA and ip1 For in the homothetic paw. Ache reaction induced by KCl in rabbit can also be lightened by administered TFA through artery vessel. Addiction would not be found while administrate TFA repeatedly and regularly. Conclusion: TFA has a satisfactory analgesic effect without addition.