| 汉族人芳香二烷基磷酸酯酶启动子-162A／G基因多态性与冠心病发病的关系 |
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| 引用本文： | 张颖,周新,霍麟,杜寒松.汉族人芳香二烷基磷酸酯酶启动子-162A／G基因多态性与冠心病发病的关系[J].职业与健康,2004,20(3):3-5. |
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| 作者姓名： | 张颖 周新 霍麟 杜寒松 |
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| 作者单位： | 1. 武汉大学中南医院,湖北省武汉市,430071
2. 华中科技大学同济医学院附属协和医院 |
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| 摘 要： | 目的 研究湖北地区汉族人芳香二烷基磷酸酯酶 (paraoxonasc ,PON1)启动子基因 -162位Ala -Gly基因多态性与冠心病 (CHD)发病的关系。方法 应用多聚酶链反应 -限制性片段长度多态性的分析方法 (PCR -RELP)检测湖北汉族地区CHD患者及正常对照组PON1基因启动子 -162位点的多态性 ,血脂用酶法测定。结果 PON1启动子 -162位点存在多态性 ,有AA ,AG ,GG 3种基因型。 12 8例正常人中AA基因型占 4 7% ,AG基因型占 2 0 3 % ,GG基因型占 75 0 % ,而CHD组与对照组 -162Ala-Gly 基因型分布总体构成比差异无显著性。对照组和CHD组PON基因G等位基因频率分别为 0 85 2和0 913 ,差异也无显著性 (P >0 0 5 )。结论 未发现PON1启动子基因 -162位Ala-Gly多态性与中国人CHD有关。
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| 关 键 词： | 芳香二烷基磷酸酯酶 启动子 冠心病 多态性 |
| 文章编号： | 1004-1257(2004)03-0003-03 |
| 修稿时间： | 2003年3月5日 |
Relationship between PON1-162A/G gene polymorphism and CHD |
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| Zhang Ying,Zhou Xin,Huo Lin.Relationship between PON1-162A/G gene polymorphism and CHD[J].Occupation and Health,2004,20(3):3-5. |
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| Authors: | Zhang Ying Zhou Xin Huo Lin |
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| Abstract: | To study the relationship between PON1- 162A/G gene polymorphism and CHD of the Han nationality in Hubei.PCR - RELP was applied in detecting PON1- 162A/G gene polymorphism of CHD group and contrast group. Polymorphism existed in PON1- 162. There were 3 kinds of genotypes: AA, AG, GG. 4.7% of 128 normal people was AA genotype, 20.3% was AG genotype, and 75.o% was GG genotype. No significant difference was found in constituent ratio of 162Ala -Gly genotype distribution between CHD group and contrast group. Gene frequencies of contrast group and CHD group were 0.852 and 0.913 respectively. No significant difference was found (P> 0.05).Conclusion]There is no relationship between PON1- 162Ala - Gly gene polymorphism and Chinese CHD. |
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| Keywords: | PON Promotor CHD Polymorphism |
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