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Synthesis of 1-(N-ethoxycarbonylamino)alkylphosphonic monoesters
Authors:H Liu  J X Xu
Affiliation:(1) Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
Abstract:Summary. A series of 1-(N-ethoxycarbonylamino)alkylphosphonic monoesters were synthesized via three-component Mannich-type condensation of ethyl carbamate, aldehydes and dichlorophosphites in benzene, followed by hydrolysis.
Keywords:: Amino acid –  Aminoalkylphosphonic acid –  Multiple-component condensation –  Mannich-type reaction –  Synthesis
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