W026B对大鼠全脑缺血再灌注损伤的保护作用

脑缺血在世界范围内严重影响着人类的生活质量和生命健康.W026B是一种新合成的木脂素衍生物,对局灶性脑缺血/再灌注模型具有保护作用,但W026B对全脑缺血/再灌注(GCI/R)模型是否具有脑保护作用尚不清楚.本文研究了W026B对四血管闭塞性全脑缺血再灌注模型是否具有脑保护作用.结果显示:W026B明显提高了GCI/R...

The protective effect of W026B on global cerebral ischemia/reperfusion injury model in rats

Cerebral ischemia seriously affects the quality of life and health of human worldwide. W026B is a newly synthesized lignan derivative that has a protective effect on the focal cerebral ischemia/reperfusion model, while it is unclear whether W026B has a cerebral protective effect on the model of global cerebral ischemia/reperfusion (GCI/R). In this study, we investigated the protective effect of W026B on the four-vessel occlusion GCI/R model. The results showed that W026B obviously increased the survival rate of rats during 7 d after GCI/R and significantly improved neurological deficits within 7 d after GCI/R. It evidently enhanced the number of survival neurons in the hippocampus of GCI/R rats. Furthermore, W026B notably lowered the level of ROS, and increased the activity of SOD in the hippocampus of GCI/R rats. Moreover, it also decreased the expression of NF-κB p65 and the level of IL-6 apparently. In addition, W026B evidently lowered the activity of caspase-3. In conclusion, this study firstly proves that W026B has the protective effect on GCI/R rats. Its cerebral protective effect maybe related to the inhibition of oxidative stress, inflammatory response, and cell apoptosis during GCI/R. These results provide new evidence with the protective effect of W026B on cerebral ischemia/reperfusion injury.