| 氢质子磁共振波谱在婴幼儿重症肠道病毒71脑炎的应用 |
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| 引用本文： | 郭予雄,何少茹,翟琼香,黄飚,钟敏泉,林晓源,桂娟.氢质子磁共振波谱在婴幼儿重症肠道病毒71脑炎的应用[J].广东医学,2011,32(15). |
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| 作者姓名： | 郭予雄 何少茹 翟琼香 黄飚 钟敏泉 林晓源 桂娟 |
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| 作者单位： | 1. 广东省人民医院、广东省医学科学院、广东省神经科学研究所PICU,广州,510080
2. 广东省人民医院、广东省医学科学院、广东省神经科学研究所放射科,广州,510080 |
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| 基金项目： | 广东省医学科研基金资助项目 |
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| 摘 要： | 目的 探讨氢质子磁共振波谱(1H-MRS)在婴幼儿重症肠道病毒71(EV71)脑炎中的早期表现及应用价值.方法 对25例婴幼儿重症EV71脑炎(病例组)进行分期,于起病5 d 内行脑干1H-MRS检查,主要检测指标为N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)及峰下面积比值NAA/Cr、Cho/Cr和NAA/Cho+Cr,并与10名健康儿童(对照组)进行比较.结果 病例组与对照组年龄的差异无统计学意义(t=0.048,P=0.962),对照组1H-MRS和MRI均未见异常.病例组Ⅱ期16例,Ⅲa期5例,Ⅲb期4例.Ⅱ期及Ⅲ期与对照组相比:Ⅱ期Cho/Cr差异无统计学意义(P>0.05),Ⅲ期Cho/Cr显著增高(P<0.05).Ⅲa期与Ⅱ期比较:Cho/Cr增高,NAA/Cho+Cr降低(均P<0.01),Ⅲb期与Ⅱ期比较:NAA/Cr、NAA/Cho+Cr降低,Cho/Cr增高(均P＜0.01).Ⅲa期与Ⅲb期相比:Ⅲb期NAA/Cr、NAA/Cho+Cr降低(分别P<0.01和P<0.05),Cho/Cr差异无统计学意义(P>0.05).结论 重症EV71脑炎早期1H-MRS表现为NAA/Cr、NAA/Cho+Cr下降,Ⅲ期伴Cho/Cr增高,提示早期神经元损害、神经元丢失或功能障碍,可伴有髓鞘破坏或胶质细胞增生;1H-MRS生化代谢改变越明显,临床症状越重,预后越差;1H-MRS有助弥补MRI不足,能敏感检测重症EV71脑炎早期脑代谢物质变化.
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| 关 键 词： | 肠道病毒71 脑炎 氢质子磁共振波谱 儿童 |
Application of proton magnetic resonance spectroscopy in infants and young children with severe enterovirus 71 encephalitis |
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| GUO Yu-xiong,HE Shao-ru,ZHAI Qiong-xiong,HUANG Biao,ZHONG Min-quan,LIN Xiao-yuan,GUI Juan.Application of proton magnetic resonance spectroscopy in infants and young children with severe enterovirus 71 encephalitis[J].Guangdong Medical Journal,2011,32(15). |
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| Authors: | GUO Yu-xiong HE Shao-ru ZHAI Qiong-xiong HUANG Biao ZHONG Min-quan LIN Xiao-yuan GUI Juan |
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| Affiliation: | GUO Yu-xiong,HE Shao-ru,ZHAI Qiong-xiong,HUANG Biao,ZHONG Min-quan,LIN Xiao-yuan,GUI Juan.Department of Pediatric Intensive Care Unit,Guangdong General Hospital,Guangdong Academy of Medical Science,Guangdong Neuroscience Institute,Guangzhou 510080,China |
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| Abstract: | Objective To investigate the early manifestation and clinical application of proton magnetic resonance spectroscopy(1H-MRS) in infants and young children with severe enterovirus 71(EV71) encephalitis. Methods 1H-MRS scan was carried out in 25 children with different stages of severe EV71 encephalitis 5 days after onset of the disease.The concentrations of N-acetyl-as-partate(NAA),Creatine(Cr) and choline contained compounds(Cho),and the NAA/Cr,Cho/Cr and NAA/(Cho+Cr) ratios of stembrain were assessed.Compar... |
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| Keywords: | enterovirus 71 encephalitis proton magnetic resonance spectroscopy children |
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