| 马来酸氯苯那敏片剂的核磁共振定量测定方法研究 |
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| 引用本文： | 郭强胜,石高旗,宋巍,许旭.马来酸氯苯那敏片剂的核磁共振定量测定方法研究[J].上海轻工业高等专科学校学报,2011(2):123-128. |
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| 作者姓名： | 郭强胜 石高旗 宋巍 许旭 |
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| 作者单位： | 上海应用技术学院化学与环境工程学院,上海200235 |
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| 摘 要： | 提出测定马来酸氯苯那敏片剂中马来酸氯苯那敏的1↑H-NMR方法。考察了实验条件的影响,选择重水为溶剂,反丁烯二酸为内标,延迟时间为20 s,脉冲宽度为3.0μs,采样次数为16次,内标浓度为4-5mg/mL。在内标与样品质量比为0.48-2.12范围内,峰面积比与质量比之间具有良好的线性关系,相关系数r〉0.999 0,用绝对定量法和标准曲线法测定了3种马来酸氯苯那敏片剂的含量,并与药典的紫外分光光度法作了比较。
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| 关 键 词： | 核磁共振 定量 马来酸氯苯那敏 |
Quantitation of Chlorphenamine Maleate in Tablet by NMR |
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| GUO Qiang-sheng,SHI Gao-qi,SONG Wei,XU Xu.Quantitation of Chlorphenamine Maleate in Tablet by NMR[J].Journal of Shanghai Institute of Technology(Natural Science),2011(2):123-128. |
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| Authors: | GUO Qiang-sheng SHI Gao-qi SONG Wei XU Xu |
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| Affiliation: | (School of Chemical and Environmental Engineering,Shanghai Institute of Technology,Shanghai 200235,China) |
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| Abstract: | A simple and accurate proton-nuclear magnetic resonance（1↑H-NMR） method for quantitative determination of chlorphenamine maleate in tablet was presented.The method employed D2O as solvent and fumaric acid as internal standard.The delay time（D1） 1.0 s,pulse width（P1） 20 μs and number of transient（NS） 16 times were selected according to investigation.The relationship between NMR peak area ratio and mass ratio of fumaric acid to chlorphenamine maleate is linear with the correlation coefficient as above 0.9990 in the linear range of 0.48～2.12 mass ratio.Three kinds of real tablet were measured and the quantitative results obtained by means of 1↑H-NMR were found to be in agreement with absolute method of quantification.The ultraviolet spectrophotometry method used in pharmacopoeia was also compared. |
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| Keywords: | 1↑H-NMR quantification chlorphenamine maleate |
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