结缔组织病相关肺动脉高压血清标记物研究现状

结缔组织病相关肺动脉高压（CTD-PAH）因其发病机制存在自身免疫和炎症反应,故其病情评估指标除适用于特发性肺动脉高压的标记物外,文献提示还可能存在以下几种血清学标记物：（1）自身抗体,如抗内皮细胞抗体、抗成纤维细胞抗体、抗β2-糖蛋白1（β2-GP1）抗体以及抗U1RNP和U3RNP抗体;（2）炎症因子,包括趋化因子（如CX3CL1,CCL2和RANTEs）、生长因子（如血小板源性生长因子等）;（3）其他血清标记物如N-末端尿钠肽原、endoglin等。这些标记物可能成为提示或预测CTD-PAH更为特异的标记物,值得进一步探讨和证实。

Serum Markers for Connective Tissue Disease Associated Pulmonary Arterial Hypertension

Autoimmunity and inflammation have been revealed in the pathogenesis of connective tissue disease associated pulmonary arterial hypertension （CTD-PAH）.It is suggested by literatures that there may be several types of serum biomarkers exclusively for CTD-PAH rather than those for idiopathic PAH.These promising markers include：（1） autoantibodies,such as anti-endothelial antibody,anti-fibroblast antibody,anti-beta2-glycoprotein 1 （GP1） antibody,anti-U1 and U3 RNP antibody;（2） inflammatory markers including chemokines （e.g.CX3CL1,CCL2 and RANTEs）,growth factors （e.g.platelet-derived growth factor）,and （3） others biomarkers,such as N-terminal brain natriuretic peptide （NT-BNP）,endoglin,etc.Further investigation and research are in demand to confirm their efficacy in predicting PAH secondary to CTD.