Renoprotective effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, on rats with chronic kidney disease |
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Authors: | Ahn Young-Min Kim Su Kang Lee Sang-Hun Ahn Se-Young Kang Sung Wook Chung Joo-Ho Kim Sung-Do Lee Byung-Cheol |
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Affiliation: | Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea. |
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Abstract: | Chronic kidney disease (CKD) is a common cause of end‐stage renal disease. Antihypertensive agents are used clinically to inhibit the progression of CKD, but cannot prevent eventual renal failure. This study investigated the effect of Tanshinone IIA, an active component of Salvia miltiorrhiza, in rats suffering from CKD induced by 5/6 nephrectomy. After development of renal insufficiency, the rats were treated with Tanshinone IIA (10 mg/kg) for 8 weeks. Serum creatinine, angiotensin II (Ang II), transforming growth factor β1 (TGF‐β1) and collagen IV levels were significantly reduced in Tanshinone IIA treated rats compared with a control group. In addition, Tanshinone IIA suppressed increases in urinary protein excretion in CKD rats. These findings suggest that chronic oral administration of Tanshinone IIA can improve renal dysfunction associated with CKD. Copyright © 2010 John Wiley & Sons, Ltd. |
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Keywords: | Tanshinone IIA renoprotection nephrectomy chronic kidney disease |
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