血清Hepcidin 水平在老年缺铁性贫血和慢性病贫血诊断中的临床应用

目的:探讨血清铁调素(Hepcidin)在老年人群缺铁性贫血(IDA)和慢性病贫血(ACD)中的应用价值。方法:选择老年IDA患者32例,老年ACD患者34例,健康对照组28例。检测对比三组血清Hepcidin、血清铁(SI)、血清铁蛋白(SF)、C-反应蛋白(CRP)、红细胞数(RBC)、血红蛋白(Hb)、红细胞比容(HCT)、红细胞平均体积(MCV)、白细胞数(WBC)水平。结果:ACD组中WBC明显高于IDA组(P0.05)。血清Hepcidin在IDA组、ACD组及对照组之间具有显著性差异(P0.05),IDA组中Hepcidin含量比对照组低,而ACD组中Hepcidin含量比对照组高(P0.05)。IDA组、ACD组中SI明显低于对照组(P0.05),而两组间无显著性差异(P0.05)。ACD组中SF、CRP均明显高于IDA组与对照组(P0.05)。Hepcidin诊断IDA组的ROC曲线下面积(AUC)值大于诊断ACD组,IDA组的诊断指数高于ACD组。结论:血清Hepcidin含量的检测对于鉴别IDA和ACD具有重要的意义。

Application of SerumHepcidin in Diagnosis of Elderly Iron Deficiency Anemia and Anemia of Chronic Disease

Objective:To explore the application value of serum hepcidin in elderly iron deficiency anemia (IDA) and anemia of chronic disease (ACD).Methods:A total of 32 elderly IDA patients, 34 elderly ACD patients, and 28 healthy people ( as control group) were selected. The levels of serum hepcidin, serum iron (SI), serum ferritin (SF), c-reactive protein (CRP), red blood count (RBC), hemoglobin(Hb), hematocrit(HCT), mean corpuscular volume(MCV) and white blood count(WBC) in the three groups were detected and compared.Results:The level of WBC in ACD group was significantly higher than that of IDA group (P<0.05). There was significant difference in the levels of serum hepcidin in IDA,ACD and control group (P<0.05),and the level of serum hepcidin in IDA group was lower than that of the control group, while the ACD group was higher than control group (P<0.05). The levels of SI in ACD and IDA groups were obviously lower than that in control group (P<0.05), but there was no significant difference between ACD group and IDA group (P>0.05). The levels of SF and CRP in ACD group were obviously higher than those in control group and IDA group(P<0.05). Hepcidin diagnosis: the area under curve (AUC) value of ROC of IDA group was higher than that of ACD group,and the diagnosis index of IDA was higher than that of ACD.Conclusion:The detection of serum hepcidin content has important significance for the identification of IDA and ACD.