| LYVE-1在甲状腺肿瘤中的表达及意义探讨 |
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| 引用本文： | 钟武,何延政,龙汉安,杨辉,曾宏,刘勇.LYVE-1在甲状腺肿瘤中的表达及意义探讨[J].泸州医学院学报,2008,31(4). |
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| 作者姓名： | 钟武 何延政 龙汉安 杨辉 曾宏 刘勇 |
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| 作者单位： | 1. 泸州医学院,附属医院血管外科,四川,泸州646000
2. 泸州医学院,病理教研室,四川,泸州646000 |
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| 摘 要： | 目的:探讨淋巴管生成因子在甲状腺肿瘤中的变化规律以及与转移的相关性,为此类疾病的预防、治疗和判断预后提供理论依据.方法:选择甲状腺肿瘤病理石蜡切片135例,亚急性甲状腺炎13例,腺瘤48例,乳头状癌38例,髓样癌10例,滤泡状癌27例,未分化癌12例,其中有淋巴结转移20例.运用免疫组化检测各标本LYVE-1的表达水平,分析对不同病理类型的甲状腺癌及有无淋巴结转移肿瘤之间LYVE-1的表达水平的关系.结果:LYVE-1所标记的甲状腺恶性肿瘤中淋巴管的密度显著高于甲状腺良性肿瘤.在甲状腺癌中,有淋巴结转移者淋巴管的密度显著高于无淋巴结转移者.在各病理类型的甲状腺癌组织中,乳头状癌组织中淋巴管的密度为11.4±8.6,髓样癌组织中淋巴管的密度为4.2±2.4,未分化癌组织中淋巴管的密度为8.8±1.8,乳头状癌与髓样癌相比较t=2.6020,P=0.0124,乳头状癌与未分化癌相比较t=2.6227,P=0.0117,在统计学上均具有显著统计学差异.结论:①在甲状腺肿瘤中LYVE-1表达是恶性肿瘤较良性肿瘤高,恶性肿瘤中表达程度由高到低依次为乳头状癌、未分化癌、滤泡状癌及髓样癌,有淋巴结转移的肿瘤较无转移的肿瘤表达升高.②LYVE-1与淋巴结转移有关.
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| 关 键 词： | 甲状腺肿瘸 淋巴管生成 |
STUDY ON THE EXPRESSION OF LYVE-1 IN THYROID NEOPLASM |
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| Zhong Wu,et al.STUDY ON THE EXPRESSION OF LYVE-1 IN THYROID NEOPLASM[J].Journal of Luzhou Medical College,2008,31(4). |
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| Authors: | Zhong Wu |
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| Affiliation: | Zhong Wu,et al Department of Angiosurgery,the Affiliated Hospital of Luzhou Medical College |
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| Abstract: | Objective: To study the difference of the expression of LYVE-1 in benign and malignant thyroid tumor with or without lymphatic metastasis,and the relationship between lymphangiogenesis and metastasis to provide theoretic basis for the prognosis of this disease.Methods: 135 pieces of paraffin embedding sections of thyroid neoplasm were chosen in this study,and there were 30 cases of thyroid adenoma,28 cases of papillary thyroid carcinoma,23 cases of medullary thyroid carcinoma,27 cases of follicular thyroid ... |
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| Keywords: | LYVE-1 |
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