多索茶碱与莫西沙星在大鼠体内药动学的相互作用

 目的考察多索茶碱和莫西沙星在大鼠体内的药动学特性及合用时的相互作用。方法采用高效液相色谱法测定大鼠给药后不同时间的多索茶碱和莫西沙星的血浆浓度。血浆浓度 时间数据用非线性程序WINNONLIN拟合，求得药动学参数。结果两药合用与单独用药时的药-时曲线基本一致,多索茶碱呈一级吸收一级开放式模型，莫西沙星呈一级吸收二室开放式模型，药动学参数无统计学差异。但多索茶碱与莫西沙星合用时，多索茶碱的代谢产物之一茶碱的AUC约是单用多索茶碱时的2倍。结论两药合用药动学上无明显的相互作用, 但莫西沙星有减慢多索茶碱的代谢产物茶碱代谢的趋势，两药可以同时服用，但应注意监测茶碱的血药浓度。

Study on pharmacokinetic interaction of doxofylline and moxifloxacin in rats

OBJECTIVE To study the pharmacokinetic interaction after oral administration of doxofylline and moxifloxacin in rats.METHODS After oral administration of doxofylline and moxifloxacin,the drug levels in plasma were measured by HPLC.The plasma concentration-time data were accessed by non-linear program (WINNOLIN) and the pharmacokinetic parameters were obtained.The interaction of the pharmacokinetics between doxofylline and moxifloxacine were evaluated by student-t test.RESULTS No significant difference was found on the pharmacokinetic parameters of doxofylline and moxifloxacine before and after co-administration.But the AUC of doxofylline's metabolite theophylline after co-administration was two times higher than single administration.CONCLUSION There was no obvious interaction of pharmacokinetics when doxofylline and moxifloxacin were co-administered.They can be taken simultaneously, but the concentration of theophylline in plasma should be monitored.